单位：[1]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China[2]Department of Surgical Intensive Care Units, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an 710061, Shaanxi, China[3]Institute of Clinical Medical Sciences, China‐Japan Friendship Hospital, Beijing 100029, China[4]Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China
Non-small cell lung cancer (NSCLC) is the most common cancer and cause of cancer-related mortality globally. Increasing evidence suggested that the long non-coding RNAs (lncRNAs) were involved in cancer-related death. To explore the possible prognostic lncRNA biomarkers for NSCLC patients, in the present study, we conducted a comprehensive lncRNA profiling analysis based on 1902 patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets. In the discovery phase, we employed 682 patients from the combination of four GEO datasets (GSE30219, GSE31546, GSE33745 and GSE50081) and conducted a seven-lncRNA formula to predict overall survival (OS). Next, we validated our risk-score formula in two independent datasets, TCGA (n=994) and GSE31210 (n=226). Stratified analysis revealed that the seven-lncRNA signature was significantly associated with OS in stage I patients from both discovery and validation groups (all P<0.001). Additionally, the prognostic value of the seven-lncRNA signature was also found to be favorable in patients carrying wild-type KRAS or EGFR. Bioinformatical analysis suggested that the seven-lncRNA signature affected patients' prognosis by influencing cell cycle-related pathways. In summary, our findings revealed a seven-lncRNA signature that predicted OS of NSCLC patients, especially in those with early tumor stage and carrying wild-type KRAS or EGFR.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871998]; Natural Science Foundation of Shaanxi ProvinceNatural Science Foundation of Shaanxi Province [2018JM7013]
第一作者单位：[1]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China[2]Department of Surgical Intensive Care Units, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an 710061, Shaanxi, China
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推荐引用方式(GB/T 7714)：
Ting Lin,Yunong Fu,Xing Zhang,et al.A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer[J].AGING-US.2018,10(9):2356-2366.doi:10.18632/aging.101550.
APA：
Ting Lin,Yunong Fu,Xing Zhang,Jingxian Gu,Xiaohua Ma...&Qifei Wu.(2018).A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer.AGING-US,10,(9)
MLA：
Ting Lin,et al."A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer".AGING-US 10..9(2018):2356-2366
