单位：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’ an Jiaotong University, Xi’an, PR China[2]Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Montreal, QC, Canada[3]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[4]Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, PR China
The accuracy of abdominal multi-parametric quantification based on dynamic contrast-enhanced ultrasound (DCEUS) is limited by out-of-plane severe distortion induced by respiratory motion. This study developed a fully automatic respiratory gating scheme by using principal component analysis to remove distortions and disturbances in free-breathing DCEUS-based quantification. Taking the known in-vitro perfusions as ground truths, we further evaluated the respiratory gating accuracy from multiple perspectives in a controllable rotary distortion flow model with out-of-plane severe distortion induced by respiratory motion. Compared with those without respiratory gating, the signal-to-clutter ratio and correlation coefficients of perfusion parameters with respiratory gating improved by 3.99 +/- 1.71 dB (p < 0.01) and 0.39 +/- 0.17 (p < 0.01), respectively. The corresponding mean square error decreased by 1893.9 +/- 763.16 (p < 0.001). Results with respiratory gating were significantly consistent with the ground truths without respiratory motion disturbances. Quantitative results demonstrated the effective removal of out-of-plane serious distortion and other disturbances induced by the respiratory kinetics on DCEUS-based quantification. The accuracy and robustness of DCEUS-based quantification were significantly improved by the proposed respiratory gating strategy, which not only benefits physicians in identifying transient hemodynamic characteristics in tumor angiogenesis, but also provides accurate diagnoses for abdominal tumors. (C) 2018 Elsevier Ltd. All rights reserved.
基金：
National Key Research and Development Program of China [2016YFC0100701]; Ministry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区工程：生物医学4 区核医学
最新[2025]版：
大类|2 区医学
小类|2 区工程：生物医学2 区核医学
JCR分区：
出版当年[2016]版：
Q3ENGINEERING, BIOMEDICALQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1ENGINEERING, BIOMEDICALQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’ an Jiaotong University, Xi’an, PR China[2]Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Montreal, QC, Canada
通讯作者：
通讯机构：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’ an Jiaotong University, Xi’an, PR China[*1]Department of Biomedical Engineering, School of LifeScience and Technology, Xi’an Jiaotong University, Xi’an 710049, PR China
推荐引用方式(GB/T 7714)：
Wang Diya,Su Zhe,Su Qiang,et al.Evaluation of accuracy of automatic out-of-plane respiratory gating for DCEUS-based quantification using principal component analysis[J].COMPUTERIZED MEDICAL IMAGING and GRAPHICS.2018,70:155-164.doi:10.1016/j.compmedimag.2018.10.004.
APA：
Wang, Diya,Su, Zhe,Su, Qiang,Zhang, Xinyu,Qu, Zhen...&Wan, Mingxi.(2018).Evaluation of accuracy of automatic out-of-plane respiratory gating for DCEUS-based quantification using principal component analysis.COMPUTERIZED MEDICAL IMAGING and GRAPHICS,70,
MLA：
Wang, Diya,et al."Evaluation of accuracy of automatic out-of-plane respiratory gating for DCEUS-based quantification using principal component analysis".COMPUTERIZED MEDICAL IMAGING and GRAPHICS 70.(2018):155-164
