单位：[1]Department of nephrology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, People’s Republic of China[2]Department of Emergency, China and Japan Friendship Hospital, Peking Union Medical College, Beijing 10073, People’s Republic of China[3]Department of Pediatric, Union Hospital, Peking Union Medical College, Beijing 10032, People’s Republic of China[4]Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, People’s Republic of China
There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation. Recent discoveries have illustrated the close link between HMGB1 and heart allograft rejection. In this review, we summarize current knowledge of the function of HMGB1 as a ligand that can evoke inflammatory responses and ultimately cause rejection after heart transplantation.
基金：
Health and Family Planning Commission of Wuhan Municipality [WX17Q25, WX17Q17]
第一作者单位：[1]Department of nephrology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, People’s Republic of China
通讯作者：
通讯机构：[1]Department of nephrology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, People’s Republic of China[4]Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, People’s Republic of China[*1]Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, People’s Republic of China[*2]Department of nephrology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Lv Qianying,Li Chao,Mo Yarui,et al.The role of HMGB1 in heart transplantation[J].IMMUNOLOGY LETTERS.2018,194:1-3.doi:10.1016/j.imlet.2017.11.014.
APA：
Lv, Qianying,Li, Chao,Mo, Yarui&He, Long.(2018).The role of HMGB1 in heart transplantation.IMMUNOLOGY LETTERS,194,
MLA：
Lv, Qianying,et al."The role of HMGB1 in heart transplantation".IMMUNOLOGY LETTERS 194.(2018):1-3
