单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China[2]Dong E E Jiao Co., Ltd, Dong’e, China[3]China-Japan Friendship Hospital, Beijing, China
Colla corii asini hydrolysates (ACCH) and ginkgo biloba extracts (EGb) possess more potent antioxidant effects when used in combination than when used alone. The mixture of ACCH and EGb at a dose ratio of 20:4(w:w) showed the highest radical scavenging activity with IC50 of 0.17 +/- 0.01, 0.43 +/- 0.02 and 1.52 +/- 0.07mg/ml against DPPH, ABTS and HO<bold></bold> free radicals, respectively. Furthermore, the inhibition of breast cancer cells MCF-7 and MDA-MB-231 proliferation increased when these cell lines were treated with a combination of ACCH and EGb for 72hr, with IC50 of 4.32 +/- 0.12mg/ml and 0.39 +/- 0.01mg/ml, respectively. The findings indicated that the mixtures of ACCH and EGb could be used to prevent and treat some diseases caused by the excessive free radicals, especially cancer. Therefore, the mixtures of ACCH and EGb might serve as a natural source of desirable antioxidant and anticancer agents for the nutraceutical and pharmaceutical industries.
基金：
Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [PYBZ710]
第一作者单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China
通讯作者：
通讯机构：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China[3]China-Japan Friendship Hospital, Beijing, China[*1]State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China[*2]China-Japan Friendship Hospital, Beijing, China.
推荐引用方式(GB/T 7714)：
Xu Xiaobing,Guo Shangwei,Hao Xianghui,et al.Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts[J].FOOD SCIENCE & NUTRITION.2018,6(4):765-772.doi:10.1002/fsn3.587.
APA：
Xu, Xiaobing,Guo, Shangwei,Hao, Xianghui,Ma, Hui,Bai, Yanping&Huang, Yaqin.(2018).Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts.FOOD SCIENCE & NUTRITION,6,(4)
MLA：
Xu, Xiaobing,et al."Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts".FOOD SCIENCE & NUTRITION 6..4(2018):765-772
