Epidemiological characterization of respiratory tract infections caused by Mycoplasma pneumoniae during epidemic and post- epidemic periods in North China, from 2011 to 2016
单位：[1]Department of Clinical Laboratory, The Third People’s Hospital of Shenzhen,Shenzhen, Guangdong, China深圳市康宁医院深圳医学信息中心[2]Department of Infectious Diseases andClinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute ofRespiratory Medicine, Capital Medical University, Beijing, China北京朝阳医院[3]Departmentof Pediatrics, Beijing Chao-Yang Hospital, Beijing Institute of RespiratoryMedicine, Capital Medical University, Beijing, China首都儿科研究所北京朝阳医院[4]Department of ClinicalTrial, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, China深圳市康宁医院深圳医学信息中心[5]Department of Respiratory and Critical Care Medicine, Clinical Microbiologyand Infectious Disease Lab, China-Japan Friendship Hospital, Beijing, China
Background: Mycoplasma pneumoniae (M. pneumoniae) is a commonly causative pathogen for respiratory tract infections (RTIs) in humans. The epidemiological features of M. pneumoniae infections during post-epidemic, including age distribution and the seasonality of the patients, are not well investigated. Methods: We retrospectively analyzed the clinical data of 7835 consecutive RTIs patients (3852 adults and 3983 children) who visited a teaching hospital, and defined an epidemic (2011-2013) and a post-epidemic period (2014-2016). M. pneumoniae was detected by fluorescence-quantatitive PCR in respiratory samples. Informed consent was obtained by all adults and the legal representatives of patients aged < 18 years, and the study was approved by Institutional Review Board of Beijing Chao-Yang Hospital (project approval number 10-KE-49). Results: The median (IQR) age was 16 (53) years (range < 0-105 years). The M. pneumoniae positive rate was 14.4% (21. 2%, epidemic; 6.7%, post-epidemic), with seasonal peaks from late summer to autumn during epidemic, and from fall to winter during post-epidemic period, which was highest in children aged 7-17 years. In epidemic, no statistical difference was found in the positive rates between children and adults among most months (except February, July and August), neither for the positive rates among age groups (P = 0.801). However, in post-epidemic period, significant differences were observed in the positive rates between children and adults in nearly every month (P<0.05 or P<0.001, except May), as well as in the positive rates among age groups (P<0.001). Most of the older patient admissions and all of ICU admissions occurred during the epidemic. Conclusions: Different patterns of age distribution and seasonality of M. pneumoniae RTIs between epidemic and post-epidemic periods were reported. Our results suggest that M. pneumoniae should be considered as a possible pathogen in pneumonia patients admitted to the ICU in the setting of an epidemic.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81400005/H0104]; Beijing Municipal Administration of Hospitals' Youth Programme [20150306]; Beijing Science and Technology Project [D101100049810002, Z131100002613001]; Shenzhen Key Laboratory of Biochip [ZDSYS201504301534057]; Special Support Fund of Shenzhen for Introduced High-Level Medical Team, Translational medicine of Biochip in clinical laboratory [SZSM201412005]
第一作者单位：[1]Department of Clinical Laboratory, The Third People’s Hospital of Shenzhen,Shenzhen, Guangdong, China[2]Department of Infectious Diseases andClinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute ofRespiratory Medicine, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, The Third People’s Hospital of Shenzhen,Shenzhen, Guangdong, China[2]Department of Infectious Diseases andClinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute ofRespiratory Medicine, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Qu Jiuxin,Yang Chunxia,Bao Fang,et al.Epidemiological characterization of respiratory tract infections caused by Mycoplasma pneumoniae during epidemic and post- epidemic periods in North China, from 2011 to 2016[J].BMC INFECTIOUS DISEASES.2018,18:doi:10.1186/s12879-018-3250-2.
APA：
Qu, Jiuxin,Yang, Chunxia,Bao, Fang,Chen, Shuyan,Gu, Li&Cao, Bin.(2018).Epidemiological characterization of respiratory tract infections caused by Mycoplasma pneumoniae during epidemic and post- epidemic periods in North China, from 2011 to 2016.BMC INFECTIOUS DISEASES,18,
MLA：
Qu, Jiuxin,et al."Epidemiological characterization of respiratory tract infections caused by Mycoplasma pneumoniae during epidemic and post- epidemic periods in North China, from 2011 to 2016".BMC INFECTIOUS DISEASES 18.(2018)
