单位：[1]Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China,[2]Immunology Section, Lund University, Lund, Sweden,[3]Department of Dermatology, Peking University People’s Hospital, Beijing, China,[4]Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China,[5]Beijing Wenfeng Tianji Pharmaceuticals Ltd., Beijing, China,[6]Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室皮肤性病科皮肤性病科首都医科大学附属北京友谊医院[7]Department of Emergency, Second Xiangya Hospital of Central South University, Changsha, China
Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells is increasing. Therefore, this review aims to summarize the current knowledge regarding the molecular regulation of Tfh cell development and differentiation at the protein level and at the epigenetic level to elucidate Tfh cell biology and provide potential targets for clinical interventions in the future.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602767, 81430074, 91442116, 81373195, 81771761]; National Basic Research Program of ChinaNational Basic Research Program of China [2014CB541904]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ3453, 2017SK2042, 2018JJ3756]; National Key Research and Development Program of China [2016YFC0903900]; Natural Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People's Republic of China
第一作者单位：[1]Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Haijing Wu,Yaxiong Deng,Ming Zhao,et al.Molecular Control of Follicular Helper T cell Development and Differentiation[J].FRONTIERS in IMMUNOLOGY.2018,9:doi:10.3389/fimmu.2018.02470.
APA：
Haijing Wu,Yaxiong Deng,Ming Zhao,Jianzhong Zhang,Min Zheng...&Qianjin Lu.(2018).Molecular Control of Follicular Helper T cell Development and Differentiation.FRONTIERS in IMMUNOLOGY,9,
MLA：
Haijing Wu,et al."Molecular Control of Follicular Helper T cell Development and Differentiation".FRONTIERS in IMMUNOLOGY 9.(2018)
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