单位：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China,首都医科大学附属同仁医院[2]National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China,首都医科大学附属北京友谊医院[3]Anyang Eye Hospital, Henan Province, China,[4]Department of Biostatistics and Epidemiology, School of Public Health, Capital Medical University, Beijing, China and[5]Lakewood Eye Care, Houston, USA
Purpose: To evaluate the effect of soft contact lens with concentric ring bifocal and peripheral add multifocal designs on controlling myopia progression in school-aged children. Methods: We systematically searched MEDLINE, EMBASE, Cochrane Library and reference lists of included trials. Methodological quality of included trials was assessed using Jadad Scale and Newcastle-Ottawa Quality Assessment Scale items. Results: We identified five randomised controlled trials (RCTs) and three cohort studies with a total of 587 myopic children. Compared with the control group, concentric ring bifocal soft contact lenses showed less myopia progression with a weighted mean difference (WMD) of 0.31 D (95% CI, 0.05 similar to 0.57 D, p = 0.02) and less axial elongation with a WMD of -0.12 mm (95% CI, approximately -0.18 to -0.07 mm, p < 0.0001) at 12 months. Relative to the control group, peripheral add multifocal soft contact lenses showed less myopia progression with a WMD of 0.22 D (95% CI 0.14 similar to 0.31 D, p < 0.0001) and less axial elongation of -0.10 mm (95% CI -0.13 similar to 0.07 mm, p < 0.0001) at 12 months, respectively. The soft contact lenses with concentric ring bifocal and peripheral add multifocal designs produced additional myopia control rates of 30 similar to 38% for slowing myopia progression and 31 similar to 51% for lessening axial elongation within 24 months. Conclusions: Both concentric ring bifocal and peripheral add multifocal soft contact lenses are clinically effective for controlling myopia in school-aged children, with an overall myopia control rates of 30 similar to 50% over 2 years. Concentric ring bifocal soft contact lenses seem to have greater effect than peripheral add multifocal soft contact lenses.
基金：
Major International (Regional) Joint Research Project of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81120108807]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81300797]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [Z121107002512055]; Major State Basic Research Development Program of China ('973' Program)National Basic Research Program of China [2011CB504601]
第一作者单位：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China,
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推荐引用方式(GB/T 7714)：
Li Shi-Ming,Kang Meng-Tian,Wu Shan-Shan,et al.Studies using concentric ring bifocal and peripheral add multifocal contact lenses to slow myopia progression in school-aged children: a meta-analysis[J].OPHTHALMIC and PHYSIOLOGICAL OPTICS.2017,37(1):51-59.doi:10.1111/opo.12332.
APA：
Li, Shi-Ming,Kang, Meng-Tian,Wu, Shan-Shan,Meng, Bo,Sun, Yun-Yun...&Wang, Ningli.(2017).Studies using concentric ring bifocal and peripheral add multifocal contact lenses to slow myopia progression in school-aged children: a meta-analysis.OPHTHALMIC and PHYSIOLOGICAL OPTICS,37,(1)
MLA：
Li, Shi-Ming,et al."Studies using concentric ring bifocal and peripheral add multifocal contact lenses to slow myopia progression in school-aged children: a meta-analysis".OPHTHALMIC and PHYSIOLOGICAL OPTICS 37..1(2017):51-59
