单位：[1]Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China[2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China[3]School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China[4]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China[5]School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China
Four new and rare iridoid glucosides, cornusfuroside A-D (1-4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473119, 81473590]; China-Japan Friendship Hospital Youth Science and Technology Excellence Project [2014-QNYC-B-10]
第一作者单位：[1]Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
He Jun,Ye XianSheng,Wang XiaoXue,et al.Four new iridoid glucosides containing the furan ring from the fruit of Corpus officinalis[J].FITOTERAPIA.2017,120:136-141.doi:10.1016/j.fitote.2017.06.003.
APA：
He, Jun,Ye, XianSheng,Wang, XiaoXue,Yang, YaNan,Zhang, PeiCheng...&Xu, JieKun.(2017).Four new iridoid glucosides containing the furan ring from the fruit of Corpus officinalis.FITOTERAPIA,120,
MLA：
He, Jun,et al."Four new iridoid glucosides containing the furan ring from the fruit of Corpus officinalis".FITOTERAPIA 120.(2017):136-141
