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Neurocalcin-delta: a potential memory-related factor in hippocampus of obese rats induced by high-fat diet

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单位： [1]School of Public Health, Beijing Key Laboratory of Enviromental Toxicology, Capital Medical University, Beijing 100069, China. [2]Department of Clinical Nutrition Beijing Friendship Hospital, Capital Medical University. [3]Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA

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关键词： Diet-induced obesity diet-resistant high fat diet neurocalcin-delta proteome

摘要：

Introduction: Aberrant protein expression within the hippocampus has recently been implicated in the pathogenesis of obesity- induced memory impairment. Objectives: The objective of the current study was to search for specific memory-related factors in the hippocampus in obese rats. Methods: Sprague-Dawley (SD) rats were fed either a high-fat (HF) diet or normal-fat (NF) diet for 10 weeks to obtain the control (CON), diet-induced obese rats (DIO) and diet-resistant (DR) rats. D-galactose was injected subcutaneously for 10 weeks to establish model (MOD) rats with learning and memory impairment. After the hippocampus of the rats sampling, the proteome analysis was conducted using two-dimensional get electrophoresis (2-DE) combined with peptide mass fingerprinting (PMF). Results: We found 15 differential proteins that expressed in the hippocampus in rats induced by HF diet from the 2-DE map. In addition, Neurocalcin-delta (NCALD) was nearly down-regulated in the DR rats compared with CON rats and MOD rats, which was further confirmed by Western blot, real-time PCR and ELISA results. Conclusion: Our data demonstrates that the differential memory-related proteins were a reflection of the HF diet, but not potential factors in obesity proneness or obesity resistance. Furthermore, NCALD is proved to be a potential hippocampus-memory related factor related to obesity.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：内科

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出版当年[2015]版：

Q3 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q3 MEDICINE, GENERAL & INTERNAL

影响因子： 最新[2023版] 0.8 最新五年平均[2021-2025] 1.3 出版当年[2015版] 0.642 出版当年五年平均[2011-2015] 0.846 出版前一年[2014版] 0.722 出版后一年[2016版] 0.635

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第一作者单位： [1]School of Public Health, Beijing Key Laboratory of Enviromental Toxicology, Capital Medical University, Beijing 100069, China.

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通讯机构： [1]School of Public Health, Beijing Key Laboratory of Enviromental Toxicology, Capital Medical University, Beijing 100069, China. [*1]School of Public Health, Beijing Key Laboratory of Enviromental Toxicology, Capital Medical University, Beijing 100069, China

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