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Involvement of Nuclear Related Factor 2 Signaling Pathway in the Brain of Obese Rats and Obesity-Resistant Rats Induced by High-Fat Diet

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收录情况： ◇ SCIE

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单位： [1]Beijing Key Laboratory of Enviromental Toxicology, School of Public Health, Capital Medical University, Beijing, China. [2]Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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关键词： diet-induced obese rat diet-resistant rats high-fat diet redox state

摘要：

We aimed to investigate the mechanism of brain damage in diet-induced obese (DIO) rats and diet-resistant (DR) rats from the viewpoint of redox state and nuclear related factor 2 (Nrf2) signaling pathway. Sprague-Dawley rats were fed with a high-fat diet for 10 weeks to obtain the DIO and DR rats. d-Galactose was injected subcutaneously through the back of the neck for 10 weeks to establish oxidative stress model rats. Then, the ratio of reduced glutathione (GSH)/oxidized glutathione (GSSG) and the level of glutathione peroxidase (GSH-Px) in serum and brain tissue were measured by using enzymatic assay kits. The levels of cholecystokinin and peptide YY in the brain tissue were detected by using enzyme-linked immunosorbent assay kits. In addition, the protein expression of Nrf2 and its downstream factors such as heme oxygenase 1, manganese superoxide dismutase, and NAD(P)H quinone oxidoreductase 1 (NQO1) in the brain tissue were measured by Western blotting. In the brain of DIO rats, the level of GSH and ratio of GSH/GSSG were lower, whereas the GSH-Px concentration was higher compared with DR rats significantly. On the other hand, the GSSG level was higher in the serum of DIO rats compared with the DR rats. The oxidative stress state in the brain of DIO rats, but not in DR rats, were observed. In addition, the protein expressions of Nrf2 and NQO1 were downregulated in the brain of DR rats compared with that in DIO rats. Our data suggest that the Nrf2/NQO1 signaling pathway and redox state were involved in the pathogenesis of the rats prone to obesity, but not the DR rats resistant to obesity.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 3 区食品科技 4 区药物化学 4 区营养学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区药物化学 4 区食品科技 4 区营养学

JCR分区：

出版当年[2014]版：

Q2 FOOD SCIENCE & TECHNOLOGY Q3 CHEMISTRY, MEDICINAL Q4 NUTRITION & DIETETICS

最新[2023]版：

Q3 FOOD SCIENCE & TECHNOLOGY Q4 CHEMISTRY, MEDICINAL Q4 NUTRITION & DIETETICS

影响因子： 最新[2023版] 1.7 最新五年平均[2021-2025] 3.4 出版当年[2014版] 1.626 出版当年五年平均[2010-2014] 1.78 出版前一年[2013版] 1.699 出版后一年[2015版] 1.844

第一作者：

第一作者单位： [1]Beijing Key Laboratory of Enviromental Toxicology, School of Public Health, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [1]Beijing Key Laboratory of Enviromental Toxicology, School of Public Health, Capital Medical University, Beijing, China. [*1]No. 10 Xitoutiao, You An Men, Beijing 100069, People’s Republic of China

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