单位：[1]Institute of Dermatology and Department of Dermatology, the First Affiliated Hospital, Anhui Medical University,[2]Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei,[3]Department of Dermatology, China-Japan Friendship Hospital, Beijing, China
We performed a gene expression study to explore whether expression levels of LBH contribute to the pathogenesis of systemic lupus erythematosus (SLE) and are associated with the genome-wide association study-identified SNP (rs7579944 and rs906868) and the SLE Disease Activity Index (SLEDAI). Fluorescent quantitative reverse transcription polymerase chain reaction was used to examine the expression of LBH mRNA in peripheral blood mononuclear cells (PBMC) from 62 SLE patients and 69 controls. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLEDAI scores, SNP rs7579944 and rs906868. This study suggests that decreased expression of LBH mRNA may be correlated with the pathogenesis of SLE.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2014CB541901, 2012CB722404, 2011CB512103]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81402590, 81371722, 81320108016, 81171505]; Research Project of Chinese Ministry of EducationMinistry of Education, China [213018A]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-0600]; Natural Science Fund of Anhui ProvinceNatural Science Foundation of Anhui Province [1408085MKL27]; Youth Science Training Program of National Natural Science Foundation of China [2010kj10]
第一作者单位：[1]Institute of Dermatology and Department of Dermatology, the First Affiliated Hospital, Anhui Medical University,
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Dermatology and Department of Dermatology, the First Affiliated Hospital, Anhui Medical University,[3]Department of Dermatology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Dermatology, China-Japan Friendship Hospital, 2 Cherry Street, Beijing 100029, China.[*2]Institute of Dermatology and Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China
推荐引用方式(GB/T 7714)：
Chang Yan,Sheng Yujun,Cheng Yuyan,et al.Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus[J].JOURNAL of DERMATOLOGY.2016,43(1):99-102.doi:10.1111/1346-8138.13006.
APA：
Chang, Yan,Sheng, Yujun,Cheng, Yuyan,Lin, Yan,Zhu, Zhengwei...&Zhang, Xuejun.(2016).Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.JOURNAL of DERMATOLOGY,43,(1)
MLA：
Chang, Yan,et al."Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus".JOURNAL of DERMATOLOGY 43..1(2016):99-102
