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TET2 Regulates LncRNA-ANRIL Expression and Inhibits the Growth of Human Gastric Cancer Cells

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收录情况： ◇ SCIE

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单位： [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]National Clinical Research Center of Digestive Diseases, Beijing, China

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关键词： TET2 gastric cancer lncRNA-ANRIL apoptosis

摘要：

Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa. Low expression of TET2 predicts poor overall and disease-free survival. Furthermore, we demonstrate that TET2 inhibits the proliferation and colony formation of human gastric cancer cells by using loss-of-function and gain-of-function strategies. Overexpression of TET2 induces apoptosis in human gastric cancer cells. The mechanism study shows that TET2 binds to the promoter region of the oncogenic long noncoding RNA (lncRNA-ANRIL) and regulates the expression of ANRIL and its downstream genes (INK4a, INK4b, and ARF). Finally, we demonstrate that ANRIL knockdown blocks the effects of TET2 on gastric cancer cell proliferation and colony formation. (C) 2016 IUBMB Life.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2014]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

影响因子： 最新[2023版] 3.7 最新五年平均[2021-2025] 4.3 出版当年[2014版] 3.143 出版当年五年平均[2010-2014] 3.372 出版前一年[2013版] 2.755 出版后一年[2015版] 2.653

第一作者：

第一作者单位： [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]National Clinical Research Center of Digestive Diseases, Beijing, China

通讯作者：

通讯机构： [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]National Clinical Research Center of Digestive Diseases, Beijing, China [*1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing 100050, China

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