单位：[1]Department of Emergency, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室急危重症及感染医学中心急诊医学科首都医科大学附属北京友谊医院[2]Liver Research Center, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室国家中心肝病分中心首都医科大学附属北京友谊医院
Acute pancreatitis (AP) is an inflammatory disease characterized by acinar cell damage, oxidative stress, and inflammation of the pancreas. Nobiletin (3',4',5,6,7,8-hexamethoxyflavone), a major polymethoxy flavone, has shown health-promoting properties in previous studies. Therefore, in this study, we investigated whether nobiletin protects against experimental AP induced with L-arginine. C57BL/6 mice were treated with 25 or 50 mg/kg nobiletin by intraperitoneal injection once daily for 14 consecutive days. AP was then induced in the mice with two intraperitoneal injections of L-arginine (4 g/kg). The nobiletin treatment significantly reduced the plasma amylase levels, pancreatic myeloperoxidase activity, percentage of pancreatic necrosis, plasma proinflammatory factors, the generation of reactive oxygen species, cell apoptosis, tissue damage, and the expression of phosphorylated p38MAPK (p-p38MAPK) and p-AKT. These results suggest that nobiletin is a new therapeutic method for L-arginineinduced AP in mice. (C) 2016 Elsevier Masson SAS. All rights reserved.
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2014]版：
Q3PHARMACOLOGY & PHARMACYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者单位：[1]Department of Emergency, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Emergency, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China[*1]Department of Emergency, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, 95 Xicheng District, Yongan Road, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Liu Bing,Huang Jian,Zhang Bin.Nobiletin protects against murine L-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT[J].BIOMEDICINE & PHARMACOTHERAPY.2016,81:104-110.doi:10.1016/j.biopha.2016.03.051.
APA：
Liu, Bing,Huang, Jian&Zhang, Bin.(2016).Nobiletin protects against murine L-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT.BIOMEDICINE & PHARMACOTHERAPY,81,
MLA：
Liu, Bing,et al."Nobiletin protects against murine L-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT".BIOMEDICINE & PHARMACOTHERAPY 81.(2016):104-110
