单位：[1]Cardiff Univ, Sch Med, Cardiff China Med Res Collaborat, Cardiff CF14 4XN, S Glam, Wales[2]Capital Med Univ, Dept Gen Surg, Beijing Key Lab Canc Invas & Metastasis Res, Beijing, Peoples R China[3]Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing, Peoples R China首都医科大学附属北京友谊医院[4]Capital Med Univ, Cardiff Univ Capital Med Univ Joint Ctr Biomed Re, Beijing, Peoples R China[5]Capital Med Univ, Inst Canc, Beijing, Peoples R China[*1]Cardiff Univ, Sch Med, Inst Canc & Genet, Cardiff China Med Res Collaborat, Heath Pk, Cardiff CF14 4XN, S Glam, Wales
Background: Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). Materials and Methods: CRC tissues (n=93) and adjacent normal colorectal tissues (n=70) were analyzed by quantitative real-time polymerase chain reaction. MTA1 knockdown was established in RKO and HT115 cells using MTA1 siRNA. Results: The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3. Conclusion: MTA1 is up-regulated in CRC. MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.
基金：
Cancer Research Wales; Life Sciences Research Network Wales (Welsh Government's Ser Cymru program); Albert Hung Foundation; China Medical Scholarship - Cardiff University
第一作者单位：[1]Cardiff Univ, Sch Med, Cardiff China Med Res Collaborat, Cardiff CF14 4XN, S Glam, Wales[2]Capital Med Univ, Dept Gen Surg, Beijing Key Lab Canc Invas & Metastasis Res, Beijing, Peoples R China[3]Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing, Peoples R China
通讯作者：
通讯机构：[*1]Cardiff Univ, Sch Med, Inst Canc & Genet, Cardiff China Med Res Collaborat, Heath Pk, Cardiff CF14 4XN, S Glam, Wales
推荐引用方式(GB/T 7714)：
Li Jun,Ye Lin,Sun Ping-Hui,et al.MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis[J].CANCER GENOMICS & PROTEOMICS.2015,12(6):339-345.
APA：
Li, Jun,Ye, Lin,Sun, Ping-Hui,Satherley, Lucy,Hargest, Rachel...&Jiang, Wen G..(2015).MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis.CANCER GENOMICS & PROTEOMICS,12,(6)
MLA：
Li, Jun,et al."MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis".CANCER GENOMICS & PROTEOMICS 12..6(2015):339-345
