The occlusion of dentinal tubules is considered to be an effective strategy to treat dentin hypersensitivity. This in vitro study introduced mesoporous silica nanoparticles (MSNs) for tubular occlusion to achieve deeper sealing. Further, MSNs with independently encapsulated calcium and phosphates (as calcium and phosphate sources) (Ca2+/PO43-@MSNs) were introduced to achieve improved efficacy of tubular occlusion and remineralization. MSNs or Ca2+/PO43-@MSNs were proportionally mixed with distilled water to make their respective desensitizing slurries, which were used to treat dentin surfaces. The efficacy of tubular occlusion was evaluated using scanning electron microscopy (SEM) images and an image analyzer, and compared with that achieved with Green-Or (TM)-a commonly used densitizer. The results demonstrated that both MSNs and Ca2+/PO43-@MSNs almost completely occluded dentinal tubules and formed a deeper seal which penetrated about 105 mu m deep into the dentinal tubules. Significant differences in tubular occlusion were observed between Green-Or (TM) densitizer and MSNs or Ca2+/PO43-@MSNs. The novel MSNs-based nanomaterials showed great potential as a treatment option for dentin hypersensitivity.
基金：
China-Japan Friendship Hospital [2010-M-25]; Capital Medical Development Scientific Research Fund [2009-3025]; NSFCNational Natural Science Foundation of China (NSFC) [50830102]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
最新[2025]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
JCR分区：
出版当年[2012]版：
Q4DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q2DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
第一作者单位：[1]China Japan Friendship Hosp, Ctr Stomatol, Beijing 100029, Peoples R China[*1]China Japan Friendship Hosp, Ctr Stomatol, 2 Yinghuayuan Dongjie, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]China Japan Friendship Hosp, Ctr Stomatol, Beijing 100029, Peoples R China[*1]China Japan Friendship Hosp, Ctr Stomatol, 2 Yinghuayuan Dongjie, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Tian Lili,Peng Ce,Shi Ying,et al.Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis[J].DENTAL MATERIALS JOURNAL.2014,33(1):125-132.doi:10.4012/dmj.2013-215.
APA：
Tian, Lili,Peng, Ce,Shi, Ying,Guo, Xuan,Zhong, Bo...&Cui, Fuzhai.(2014).Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis.DENTAL MATERIALS JOURNAL,33,(1)
MLA：
Tian, Lili,et al."Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis".DENTAL MATERIALS JOURNAL 33..1(2014):125-132
