The magnetite (Fe3O4) nanoparticles were prepared by coprecipitation of Fe3+ and Fe2+ using ammonium hydroxide (NH4OH) as a precipitating agent. The Fe3O4/polyethylene glycol (PEG) magnetic composite nanoparticles with a core-shell structure with a diameter of 10-40 nm were prepared by two step additions of the primary and the secondary surfactants, respectively. The inductive heat property of Fe3O4/PEG composite nanoparticles in an alternating current (AC) magnetic field was investigated. The potential of Fe3O4/PEG nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, Ms, and coercivity, Hc, are 67.06 emu g(-1) and 7 Oe for Fe3O4 nanoparticles and 64.11 emu g(-1) and 14 Oe for Fe3O4/PEG composite nanoparticles, respectively. Exposed in the AC magnetic field for 100 s, the temperatures of physiological saline suspensions containing Fe3O4 nanoparticles or Fe3O4/PEG composite nanoparticles are 89.2 degrees C and 72.2 degrees C, respectively. The Fe3O4/PEG composite nanoparticles will be useful as good thermoseeds for localized hyperthermia treatment of cancers. (C) 2010 Elsevier BM. All rights reserved.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [50672004]; National High-Tech Research and Development ProgramNational High Technology Research and Development Program of China [2008AA03Z513]
第一作者单位:[1]Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Zhao Dong-Lin,Teng Pan,Xu Ying,et al.Magnetic and inductive heating properties of Fe3O4/polyethylene glycol composite nanoparticles with core-shell structure[J].JOURNAL of ALLOYS and COMPOUNDS.2010,502(2):392-395.doi:10.1016/j.jallcom.2010.04.177.
APA:
Zhao, Dong-Lin,Teng, Pan,Xu, Ying,Xia, Qi-Sheng&Tang, Jin-Tian.(2010).Magnetic and inductive heating properties of Fe3O4/polyethylene glycol composite nanoparticles with core-shell structure.JOURNAL of ALLOYS and COMPOUNDS,502,(2)
MLA:
Zhao, Dong-Lin,et al."Magnetic and inductive heating properties of Fe3O4/polyethylene glycol composite nanoparticles with core-shell structure".JOURNAL of ALLOYS and COMPOUNDS 502..2(2010):392-395