单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac & Cardiovasc Surg, Beijing 100050, Peoples R China临床科室心血管中心心外科首都医科大学附属北京友谊医院[2]Chinese Acad Med Sci, Inst Canc, Natl Lab Mol Oncol, Beijing 100021, Peoples R China[3]Peking Union Med Coll, Beijing 100021, Peoples R China
Fra-1 is thought to play an important role in tumorigenesis and progression. This study aimed to investigate the expression and significance of Fra-1 in non-small-cell lung cancer (NSCLC). By analyzing with Western blot and immunohistochemistry, we found that Fra-1 is downregulated in NSCLC, compared with normal bronchial epithelium. Further, the low expression of Fra-1 correlates with advanced tumor stage and poor survival. Meanwhile, the distinct cytoplasmic location of Fra-1 was found in almost all immunoreactive cells. These findings reveal a potential nontranscriptional function of Fra-1, and indicate that Fra-1 might play a role in the progression and prognosis of NSCLC.
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac & Cardiovasc Surg, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac & Cardiovasc Surg, Beijing 100050, Peoples R China[*1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac & Cardiovasc Surg, 95 Yongian Rd, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Ma Kai,Chang Dong,Gong Min,et al.Expression and Significance of FRA-1 in Non-Small-Cell Lung Cancer[J].CANCER INVESTIGATION.2009,27(3):353-359.doi:10.1080/07357900802254008.
APA：
Ma, Kai,Chang, Dong,Gong, Min,Ding, Fang,Luo, Aiping...&Wang, Tianyou.(2009).Expression and Significance of FRA-1 in Non-Small-Cell Lung Cancer.CANCER INVESTIGATION,27,(3)
MLA：
Ma, Kai,et al."Expression and Significance of FRA-1 in Non-Small-Cell Lung Cancer".CANCER INVESTIGATION 27..3(2009):353-359
