单位：[1]Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan[2]China Japan Friendship Hosp, Dept Nephrol, Beijing, Peoples R China[3]Beijing Union Hosp, Dept Nephrol, Beijing, Peoples R China[*1]Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol,Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan
Aim: In order to understand the nutritional status of nondialytic patients with chronic renal failure (CRF), nutritional assessment was made in 20 nondialytic patients (15 males and 5 females; mean age 43.7 +/- 15.1 years). Methods: Twenty CRF inpatients were selected for nutritional assessment, and 20 normal subjects served as controls. The serum insulin-like growth factor 1 (IGF-1) concentration was measured by ELISA. Serum albumin, prealbumin, and transferrin levels were also determined. Results: The mean IGF-I and transferrin levels in the CRF patients were significantly lower than those in normal subjects (IGF-1: 176.2 +/- 92.5 mug/l vs. 266.7 +/- 101.7 mug/l, p < 0.01; transferrin: 2.57 +/- 0.58 g/l vs. 3.18 +/- 0.27 g/l, p < 0.05). The IGF-1 levels in 7 patients with a serum albumin concentration <40.0 g/l were significantly lower than those in 13 patients with a serum albumin concentration >40.0 g/l (95.6 +/- 42.4 mug/l vs. 219.6 +/- 82.7 mug/l, p < 0.01). The IGF-1 levels in cases treated with a-ketoacid were higher than in those without a-ketoacid treatment. The IGF-1 levels were positively correlated with creatinine clearance (r = 0.7066, p < 0.01) and serum transferrin concentration (r = 0.5347, p < 0.05). Conclusions: The fact that serum IGF-1 was correlated with serum transferrin and creatinine clearance suggests that IGF-1 may be a good indicator for assessing the nutritional status of CRF patients. The serum IGF-1 level in CRF patients is probably lower than that in normal subjects and could be improved by nutritional therapy. Copyright (C) 2002 S. Karger AG, Basel.
