单位：[1]State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China[2]Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室胸外科胸外科首都医科大学附属北京友谊医院
Esophageal stent implantation is an effective treatment for esophageal cancer. Current clinically-used esophageal stents are non-degradable metallic stents, such as nitinol and stainless steel, which displayed poor compliance and histocompatibility, and resulted in serious complications, such as esophageal restenosis, perforation, chest pain, etc. Thus, biodegradable esophageal stents are in eager need of investigation. Based on this, we evaluated the in vitro performance of newly-developed Zn-0.1Li alloy systematically, as a pilot study on its feasibility of applying in esophageal stent material. The degradation rate of Zn-0.1Li alloy in phosphate buffer saline (PBS) was 0.056 +/- 0.016 mm/year, and in simulated gastric fluid (SGF) was 0.316 +/- 0.022 mm/year. Zn-0.1Li alloy could maintain 95% of the initial mechanical strength after 60 days immersion. Besides, Zn-0.1Li alloy could partly inhibit L929 cell proliferation, which might be beneficial for esophageal cancer treatment. (C) 2020 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51931001, 51901003, 81771039]; Peking University Medicine Seed Fund for Interdisciplinary Research [BMU2018ME005]
第一作者单位：[1]State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
通讯作者：
推荐引用方式(GB/T 7714)：
Guo H,He Y,Zheng Y,et al.In vitro studies of biodegradable Zn-0.1Li alloy for potential esophageal stent application[J].MATERIALS LETTERS.2020,275:doi:10.1016/j.matlet.2020.128190.
APA：
Guo, H,He, Y,Zheng, Y&Cui, Y.(2020).In vitro studies of biodegradable Zn-0.1Li alloy for potential esophageal stent application.MATERIALS LETTERS,275,
MLA：
Guo, H,et al."In vitro studies of biodegradable Zn-0.1Li alloy for potential esophageal stent application".MATERIALS LETTERS 275.(2020)
