单位：[1]Department of Otolaryngology–Head and Neck Surgery Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[2]Section of Otolaryngology–Head and Neck Surgery, Department of Surgery University of Chicago, Chicago, Illinois, U.S.A.[3]Department of Otolaryngology–Head and Neck Surgery Hospital of Renmin University of China, Beijing, China[4]Department of Otolaryngology–Head and Neck Surgery,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.首都医科大学附属安贞医院
Objectives/Hypothesis To investigate causative viruses in patients with postviral olfactory disorders (PVOD). Study Design Case-control study. Methods One hundred fifty-one consecutive patients diagnosed with PVOD were enrolled, and samples from 38 patients who visited the doctor within 3 months of symptom onset were collected and analyzed. Thirty-two individuals who underwent surgery for nasal septal deviation during the same time period were collected as the control group. The Sniffin' Sticks psychophysical olfactory test was used to evaluate olfactory function. Olfactory cleft specimens were collected using nasopharyngeal flocked swabs (COPAN FLOQSwabs). Eighteen viruses were tested for with the Luminex xTAG RVP FAST v2 Assay Kit. Results Out of the 38 patients with PVOD, rhinoviruses were detected in 13 patients, and coronavirus OC43 was detected in one patient. The frequency of positive virus detection in the patients with anosmia was higher than in those with hyposmia (58.8% vs. 19.0%,P= 0.018). In control group, rhinovirus was identified in one patient (3.1%). Nasal obstruction was the most common symptom and was experienced by 71.0% of patients. Conclusions Rhinovirus and coronavirus are more commonly identified in PVOD. Our methods represent an approach to screen for viruses that may be involved in PVOD. Level of Evidence 4Laryngoscope, 2020
基金：
National Natural Science Foundation of the government of ChinaNational Natural Science Foundation of China (NSFC) [81271062]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区耳鼻喉科学4 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区耳鼻喉科学
JCR分区：
出版当年[2019]版：
Q1OTORHINOLARYNGOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1OTORHINOLARYNGOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Department of Otolaryngology–Head and Neck Surgery Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[4]Department of Otolaryngology–Head and Neck Surgery,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.[*1]Department of Otolaryngology–Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing City, 100029, China
推荐引用方式(GB/T 7714)：
Tian Jun,Pinto Jayant M.,Li Li,et al.Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction[J].LARYNGOSCOPE.2021,131(1):158-164.doi:10.1002/lary.28997.
APA：
Tian, Jun,Pinto, Jayant M.,Li, Li,Zhang, Sanmei,Sun, Zhifu&Wei, Yongxiang.(2021).Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.LARYNGOSCOPE,131,(1)
MLA：
Tian, Jun,et al."Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction".LARYNGOSCOPE 131..1(2021):158-164
