Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial
单位：[1]Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of EndocrineDiseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China[2]The Third People’s Hospital of Dalian (Dalian Third People’s Hospital Affiliated to Dalian Medical University), Dalian, 116000,China[3]China-Japan Friendship Hospital, Beijing, 100029, China[4]Shanxi Province People’s Hospital, Taiyuan, 030032, China[5]West China Hospital, Sichuan University, Chengdu, 610211, China四川大学华西医院[6]Xiangya Second Hospital of Central South University, Changsha, 210009, China[7]Xijing Hospital, Fourth Military Medical University, Xi’an, 400039, China[8]The Third Affiliated Hospital of Sun Yatsen University, Guangzhou, 510630, China中山大学附属第三医院[9]Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, 201303, China[10]Chinese People’s Liberation Army General Hospital, Beijing, 100039, China[11]Gansu Provincial Hospital, Lanzhou, 730000, China[12]Beijing Chao Yang Hospital, Beijing, 100020, China北京朝阳医院
Using the data from the trial of Metformin and AcaRbose in Chinese as the initial Hypoglycemic treatment (MARCH), this study was performed to compare the differential effects of acarbose and metformin on glucose metabolism after stratification by gender. Six hundred and forty patients who had finished the whole 48-week follow-up were included. The reduction of haemoglobin A1c (HbA(1c)) was comparable between acarboseand metformin-treated patients among either females or males, and it was also similar between males and females treated with either acarbose or metformin for 24 and 48 weeks. The dropping of fasting plasma glucose (FPG) in acarbose-treated females was significantly less than that in metformin-treated females at both 24 and 48 weeks. Furthermore, the decrease of 2-hour postprandial glucose (2hPPG) in acarbose-treated males was significantly greater than that in metformin-treated males at both 24 and 48 weeks. Multiple linear regression analysis showed that drug selection was an independent factor affecting the decrease of FPG in female patients while it independently influenced 2hPPG in males at week 24 and 48. The reductions of FPG and 2hPPG at week 24 and 48 were also significantly different between metformin-treated females and metformin-treated males although gender was not an independent regulating factor. Our study indicates that there might be gender-differential effects on FPG and 2hPPG reduction when the comparisons are made between acarbose and metformin treatments.
第一作者单位：[1]Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of EndocrineDiseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China[2]The Third People’s Hospital of Dalian (Dalian Third People’s Hospital Affiliated to Dalian Medical University), Dalian, 116000,China
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of EndocrineDiseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China[*1]Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, Liaoning 110001, China
推荐引用方式(GB/T 7714)：
Li Jianxin,Li Jing,Shan Zhongyan,et al.Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial[J].ENDOCRINE JOURNAL.2021,68(1):69-79.
APA：
Li Jianxin,Li Jing,Shan Zhongyan,Yang Wenying,Liu Jie...&Yang Zhaojun.(2021).Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial.ENDOCRINE JOURNAL,68,(1)
MLA：
Li Jianxin,et al."Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial".ENDOCRINE JOURNAL 68..1(2021):69-79
