单位：[1]Cheeloo College of Medicine, Shandong University, Jinan, China,[2]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China,[3]Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, China,[4]Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China,[5]National Clinical Research Center for Mental Disorders, Changsha, China,[6]Department of Neurology, China-Japan Friendship Hospital, Beijing, China,[7]Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China,[8]Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Institute of Aging, School of Mental Health, Wenzhou Medical University, Wenzhou, China,[9]The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China,[10]Oujiang Laboratory, Wenzhou, China,[11]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China
Multiple risk factors of stroke are associated with telomere length shortening. Although leukocyte telomere length (LTL) is shorter in patients with stroke, the heterogeneity is high. Risk factors may be differentially associated with LTL in male and female patients contributing to the heterogeneity. However, the gender difference in associations between LTL and risk factors in stroke patients has not been investigated. In this study, we investigated the gender difference in associations between LTL and risk factors in 312 stroke patients. Real-time quantitative PCR was used to determine relative LTL, and multiple linear regression analysis was applied for association analyses. We found that LTL was negatively associated with triglyceride (TG) in all patients [beta(95% CI) = -0.69 (-1.26, -0.11), P < 0.05] after adjusting confounders. Importantly, LTL was negatively associated with lack of exercise [beta(95% CI) = -1.80 (-3.12, -0.49), P < 0.05] and LDL levels [beta(95% CI) = -3.22 (-6.05, -0.390), P < 0.05] in male patients, while LTL was negatively associated with dyssomnia [beta(95%CI) = -2.00 (-3.96, -0.07), P < 0.05] and diabetes [beta(95%CI) = -2.13 (-4.10, -0.27), P < 0.01] in female patients. Our study showed that LTL is differently associated with risk factors in male and female patients with stroke, indicating that gender difference should be considered when LTL is potentially applied as an index of risk and prognosis for stroke. Our study also provides an insight into that gender differences should be considered when developing intervention strategies for stroke prevention and treatment.
基金：
Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2018BC022]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771147, 81971019]; NSFC cultivation project of Jining Medical University [JYP2018KJ09]
第一作者单位：[1]Cheeloo College of Medicine, Shandong University, Jinan, China,[2]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China,
共同第一作者：
通讯作者：
通讯机构：[8]Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Institute of Aging, School of Mental Health, Wenzhou Medical University, Wenzhou, China,[9]The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China,[10]Oujiang Laboratory, Wenzhou, China,[11]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China
推荐引用方式(GB/T 7714)：
Yuqing Wang,Fengjuan Jiao,Huancheng Zheng,et al.Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke[J].FRONTIERS in AGING NEUROSCIENCE.2021,13:doi:10.3389/fnagi.2021.719538.
APA：
Yuqing Wang,Fengjuan Jiao,Huancheng Zheng,Qingsheng Kong,Ran Li...&Yili Wu.(2021).Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke.FRONTIERS in AGING NEUROSCIENCE,13,
MLA：
Yuqing Wang,et al."Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke".FRONTIERS in AGING NEUROSCIENCE 13.(2021)
