单位:[1]Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[3]Medical School, Xizang Minzu University, Xianyang, China.[4]Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
Background: Alzheimer's disease dementia (ADD) is an important health problem in the world. Objective: The present study investigated the validity and reliability of a new version of the Frontal Assessment Battery (FAB) named the FAB-phonemic (FAB-P). Methods: A total of 76 patients with ADD, 107 patients with amnestic mild cognitive impairment (aMCI), 37 patients with non-amnestic MCI (naMCI), and 123 healthy controls were included in this study. All participants were evaluated with the FAB-P and the cognitive assessments according to a standard procedure. Results: The global FAB-P scores in patients withADDwere lower than those of patients with aMCI, patients with naMCI, and healthy controls (p < 0.001). Patients with aMCI performed worse than healthy controls (p < 0.001). The interrater reliability, test-retest reliability, and Cronbach's alpha coefficient for the FAB-P were 0.997, 0.819, and 0.736, respectively. The test could distinguish the patients with mild ADD, aMCI, and naMCI from healthy controls with classification accuracy of 89.4%, 70.9%, and 61.6%, respectively. It could also discriminate between the patients with ADD and aMCI, between those with ADD and naMCI, and between those with aMCI and naMCI with classification accuracy of 73.8%, 83.9%, and 58.0%, respectively. The regression analysis revealed that the Montreal Cognitive Assessment and the Stroop Color Word Test Part C had the greatest contribution to FAB-P score variance. Conclusion: The FAB-P is a valid and reliable tool for evaluating frontal lobe function and can effectively discriminate ADD, aMCI, and naMCI.
基金:
China-Japan Friendship Hospital [2014-4-QN-32]; Personnel development funding projects of Beijing Dongcheng District [DCQYYRC-791-01-DR]; Key Projects of Strategic International Cooperation in Scientific and Technological Innovation in National Key Research and Development Program [2018YFE0203600]
第一作者单位:[1]Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[*1]Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, South 4th Ring Road West 119, Beijing 100070, China
通讯作者:
通讯机构:[1]Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[*1]Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, South 4th Ring Road West 119, Beijing 100070, China
推荐引用方式(GB/T 7714):
Li Xudong,Shen Miaoxin,Jin Yi,et al.Validity and Reliability of the New Chinese Version of the Frontal Assessment Battery-Phonemic[J].JOURNAL of ALZHEIMERS DISEASE.2021,80(1):371-381.doi:10.3233/JAD-201028.
APA:
Li Xudong,Shen Miaoxin,Jin Yi,Jia Shuhong,Zhou Zhi...&Jiao Jinsong.(2021).Validity and Reliability of the New Chinese Version of the Frontal Assessment Battery-Phonemic.JOURNAL of ALZHEIMERS DISEASE,80,(1)
MLA:
Li Xudong,et al."Validity and Reliability of the New Chinese Version of the Frontal Assessment Battery-Phonemic".JOURNAL of ALZHEIMERS DISEASE 80..1(2021):371-381