单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China[2]Dental Medical Center, ChinaJapan Friendship Hospital, Beijing 100029, People’s Republic of China
In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nanoclusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semi-conductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.
基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [51873016]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [JD2014]; Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) [XK2020-11]
第一作者单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China
通讯作者：
通讯机构：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China[2]Dental Medical Center, ChinaJapan Friendship Hospital, Beijing 100029, People’s Republic of China[*1]Dental Medical Center, ChinaJapan Friendship Hospital, Beijing 100029, People’s Republic of China[*2]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China
推荐引用方式(GB/T 7714)：
Wan Jiafeng,Zhang Xiaoyuan,Zhang Kai,et al.Biological nanoscale fluorescent probes: From structure and performance to bioimaging[J].REVIEWS in ANALYTICAL CHEMISTRY.2020,39(1):209-221.doi:10.1515/revac-2020-0119.
APA：
Wan, Jiafeng,Zhang, Xiaoyuan,Zhang, Kai&Su, Zhiqiang.(2020).Biological nanoscale fluorescent probes: From structure and performance to bioimaging.REVIEWS in ANALYTICAL CHEMISTRY,39,(1)
MLA：
Wan, Jiafeng,et al."Biological nanoscale fluorescent probes: From structure and performance to bioimaging".REVIEWS in ANALYTICAL CHEMISTRY 39..1(2020):209-221
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