Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy
单位：[a]Beijing Friendship Hospital, Capital Medical University, Beijing Institute of Clinical Pharmacy, Beijing 100050, PR China首都医科大学附属北京友谊医院[b]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, PR China[c]Department of Electrical Engineering City, University of Hong, Kong 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, PR China
Ultrathin two-dimensional (2D) nanosheets (NSs) have been widely explored as nanoagents for multimodal cancer therapies, such as photothermal therapy (PTT) combined with chemodynamic therapy (CDT). However, it is still a challenge to prepare 2D NSs with good performance in both CDT and NIR-II PTT. Here, we report the preparation of ultrathin 2D CuFe2S3 NSs as an efficient nanoagent for synergistic CDT and NIR-II PTT to ablate cancer cells/tumors. Ultrathin 2D CuFe2S3 NSs are first prepared by sulfurization of ultrathin CuFe-LDH NSs via a simple hydrothermal treatment. After modification with polyethylene glycol (PEG), the PEG-modified CuFe2S3 NSs (CuFe2S3-PEG) show broadband NIR-II absorption and excellent photothermal conversion efficiency (-55.86%) at 1064 nm. Moreover, the overproduced glutathione in the tumor microenvironment can react with CuFe2S3-PEG NSs to release Fe2+ and Cu+, thus activating Fenton reaction to efficiently produce hydroxyl radicals (center dot OH). Importantly, the photothermal effect of CuFe2S3-PEG could further synergistically improve the Fenton reaction by increasing the local temperature. In vitro and in vivo results reveal that the CuFe2S3-PEG has remarkable synergistic CDT/PTT antitumor activity. This study has proven that the metal chalcogenide NSs of CuFe2S3-PEG can be used as an efficient nanoagent for multimodal cancer therapies, which could also be promising in other applications like biosensors, drug delivery and antibacterial.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC: 21971007, 21521005, 21671013, 21601010]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [XK1802-6, XK1803-05]; City University of Hong KongCity University of Hong Kong [9610495]
第一作者单位：[a]Beijing Friendship Hospital, Capital Medical University, Beijing Institute of Clinical Pharmacy, Beijing 100050, PR China[b]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang S,Hu T,Wang G,et al.Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy[J].CHEMICAL ENGINEERING JOURNAL.2021,419:doi:10.1016/j.cej.2021.129458.
APA：
Wang, S,Hu, T,Wang, G,Wang, Z,Yan, D...&Tan, C.(2021).Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy.CHEMICAL ENGINEERING JOURNAL,419,
MLA：
Wang, S,et al."Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy".CHEMICAL ENGINEERING JOURNAL 419.(2021)
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