单位：[1]Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[3]Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[4]Information Center, China-Japan Friendship Hospital, Beijing, China[5]Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China[6]Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China[7]Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
BACKGROUND: CPNEs are significant biomarkers which can affect the progression and prognosis of various tumor diseases. However, the prognosis role of CPNEs in multiple myeloma (MM) is still unclear. OBJECTIVES: To investigate the prognosis role of CPNEs in MM. METHODS: Seven hundred and thirty-five samples from two independent data sets were involved to analyze the clinical and molecular characteristics, and prognosis role of the expression of CPNE1-9 in MM. RESULTS: MM patients with higher expressions of CPNE5 and CPNE9 had longer event-free survival (EFS) and overall survival (OS) compared with CPNE5(low) and CPNE9(low) expression groups (EFS: P = 0.0054, 0.0065; OS: P = 0.015, 0.016, respectively). Multivariate regression analysis showed that CPNE5 was an independent favorable predictor for EFS and OS (EFS: P = 0.005; OS: P = 0.006), and CPNE9 was an independent positive indicator for EFS (P = 0.002). Moreover, the survival probability and the cumulative event of EFS and OS in CPNE5(high) CPNE9(high) group were significantly longer than other groups. CONCLUSIONS: High expressions of CPNE5 and CPNE9 might be used as positive indicators for MM, and their combination was a better predictor for the survival of MM patients.
基金：
Xinjiang Joint Fund of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1903117]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500118]
第一作者单位：[1]Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[3]Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[3]Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[5]Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China[6]Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China[7]Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China[*1]Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China[*2]Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China
推荐引用方式(GB/T 7714)：
Zhu Pei,Qian Tingting,Si Chaozeng,et al.High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma[J].CANCER BIOMARKERS.2021,31(1):77-85.doi:10.3233/CBM-203108.
APA：
Zhu Pei,Qian Tingting,Si Chaozeng,Liu Yan,Cui Longzhen...&Zeng Tiansheng.(2021).High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma.CANCER BIOMARKERS,31,(1)
MLA：
Zhu Pei,et al."High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma".CANCER BIOMARKERS 31..1(2021):77-85
