单位：[1]Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China[2]Department of Pathology, China-Japan Friendship Hospital, Beijing, China[3]Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China[4]Department of the Clinical Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China
Evidence has demonstrated that miRNAs play an irreplaceable role in tumorigenesis and progression of a broad range of cancers, including gastric cancer. Among these miRNAs, miR-10a and miR-10b have been identified to critically participate in gastric carcinogenesis and malignant progression. In this review, we briefly describe the role of miR-10a and miR-10b in gastric cancer, especially in the regulation of cell proliferation, apoptosis, cell cycle, migration, invasion and metastasis, drug resistance, and cancer stem cells. Furthermore, we highlight several compounds that target the miR-10 family and exhibit antitumor activity in cancer cells. Moreover, we conclude that targeting the miR-10 family might be a promising approach for the treatment of gastric cancer.
第一作者单位：[1]Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China
通讯作者：
通讯机构：[3]Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China[4]Department of the Clinical Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China[*1]Department of the Clinical Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China[*2]Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China
推荐引用方式(GB/T 7714)：
Liu Fang,Shi Yanfen,Liu Zuolong,et al.The emerging role of miR-10 family in gastric cancer[J].CELL CYCLE.2021,20(15):1468-1476.doi:10.1080/15384101.2021.1949840.
APA：
Liu, Fang,Shi, Yanfen,Liu, Zuolong,Li, Ziyi&Xu, Wei.(2021).The emerging role of miR-10 family in gastric cancer.CELL CYCLE,20,(15)
MLA：
Liu, Fang,et al."The emerging role of miR-10 family in gastric cancer".CELL CYCLE 20..15(2021):1468-1476
