单位：[1]Second Hosp Shaoxing City, Dept Gastroenterol, Shaoxing 312000, Zhejiang, Peoples R China[2]China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
MicroRNAs (miRNAs), a class of small noncoding RNAs, play critical roles in human carcinogenesis through downregulation of various target genes. In the present study, we found that miR-92 is upregulated in gastric cancer tissues compared with adjacent normal tissues. Interestingly, miR-92 expression is significantly associated with clinical characteristics of patients. Gain or loss-of-function in vitro experiments further show that miR-92 mimics significantly promoted, while its antisense oligos inhibited gastric cancer cell proliferation and invasion. Moreover, luciferase reporter assays and western blot indicated that farnesoid X receptor (FXR), is a direct target of miR-92. Therefore, our data suggest that upregulation of miR-92 may represent an important mechanism for the development of gastric cancer.
第一作者单位：[1]Second Hosp Shaoxing City, Dept Gastroenterol, Shaoxing 312000, Zhejiang, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Duan Jian-Hua,Fang Long.RETRACTED: MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR (Retracted article. See April, 2017)[J].TUMOR BIOLOGY.2014,35(11):11013-11019.doi:10.1007/s13277-014-2342-x.
APA：
Duan, Jian-Hua&Fang, Long.(2014).RETRACTED: MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR (Retracted article. See April, 2017).TUMOR BIOLOGY,35,(11)
MLA：
Duan, Jian-Hua,et al."RETRACTED: MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR (Retracted article. See April, 2017)".TUMOR BIOLOGY 35..11(2014):11013-11019
