单位：[1]Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China,[2]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China,[3]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China,[4]National Center for Respiratory Medicine, Beijing, China,[5]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China,[6]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Disease, Beijing, China
Background: We performed a meta-analysis to systematically review the risk factors of mortality from non-HIV-related Pneumocystis pneumonia (PcP) and provide the theoretical basis for managing non-HIV-related PcP. Methods: PubMed, Embase, Web of Science, the Cochrane Library and CNKI databases were searched. A meta-analysis of the risk factors of mortality from non-HIV-related PcP was conducted. Results: A total of 19 studies and 1,310 subjects were retrieved and included in the meta-analysis, including 485 and 825 patients in the non-survivor and survivor groups, respectively. In the primary analysis, age, concomitant with other pulmonary diseases at diagnosis of PcP, solid tumors, cytomegalovirus(CMV) co-infection, lactate dehydrogenase (LDH), lymphocyte count, invasive ventilation during hospitalization, and pneumothorax were associated with mortality from non-HIV-related PcP, whereas sex, albumin, PcP prophylaxis, use of corticosteroids after admission, and time from onset of symptoms to treatment were not associated with mortality from non-HIV-related PcP. Conclusions: The mortality rate of non-HIV-infected patients with PcP was still high. Age, concomitant with other pulmonary diseases at diagnosis of PcP, solid tumors, CMV co-infection, LDH, lymphocyte count, invasive ventilation during hospitalization, and pneumothorax were risk factors of mortality from non-HIV-related PcP. Improved knowledge of prognostic factors is crucial to guide early treatment.
基金：
Zhejiang University special scientific research fund for COVID-19 prevention and control [2020XGZX008]
第一作者单位：[1]Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China,
通讯作者：
通讯机构：[3]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China,[4]National Center for Respiratory Medicine, Beijing, China,
推荐引用方式(GB/T 7714)：
Yuqiong Wang,Xiaoyi Zhou,Maidinuer Saimi,et al.Risk Factors of Mortality From Pneumocystis Pneumonia in Non-HIV Patients: A Meta-Analysis[J].FRONTIERS in PUBLIC HEALTH.2021,9:doi:10.3389/fpubh.2021.680108.
APA：
Yuqiong Wang,Xiaoyi Zhou,Maidinuer Saimi,Xu Huang,Ting Sun...&Qingyuan Zhan.(2021).Risk Factors of Mortality From Pneumocystis Pneumonia in Non-HIV Patients: A Meta-Analysis.FRONTIERS in PUBLIC HEALTH,9,
MLA：
Yuqiong Wang,et al."Risk Factors of Mortality From Pneumocystis Pneumonia in Non-HIV Patients: A Meta-Analysis".FRONTIERS in PUBLIC HEALTH 9.(2021)
