单位：[1]Medical ICU, Peking Union Medical College Hospital, Peking Union MedicalCollege and Chinese Academy of Medical Sciences, 1 Shuaifuyuan,Dongcheng district, Beijing 100730, China[2]Department of Respiratory andCritical Care Medicine, China-Japan Friendship Hospital, 2 Yinghua Dongjie,Hepingli, Beijing 100029, China[3]Department of General Internal Medicine,Shijingshan hospital, Capital Medical University, 24 Shijingshan street,Shijingshan district, Beijing 100043, China[4]Intensive Care Unit, Fifth Hospitalof Shi Jia Zhuang, 42 Tanan street, Yuhua district, Shijiazhuang 050021,China
Background: Pneumocystis jiroveci pneumonia (PJP) in non-HIV patients is still a challenge for intensivists. The aim of our study was to evaluate mortality predictors of PJP patients requiring Intensive care unit (ICU) admission. Methods: Retrospectively review medical records of patients with diagnosis of PJP admitted to four ICUs of two academic medical centers from October 2012 to October 2015. Results: Eighty-two patients were enrolled in the study. Overall hospital mortality was 75.6 %. Compared with survivors, the non-survivors had older age (55 +/- 16 vs. 45 +/- 17, p = 0.014), higher APACHE II score (20 +/- 5 vs. 17 +/- 5, p = 0.01), lower white blood cell count (7.68 +/- 3.44 vs. 10.48 +/- 4.62, p = 0.005), less fever (80.6% vs. 100 %, p = 0.033), more hypotension (58.1 % vs. 20 %, p = 0.003), more pneumomediastinum (29 % vs. 5 %, p = 0.027). Logistic regression analysis demonstrated that age [odds ratio (OR) 1.051; 95 % CI 1.007-1.097; p = 0.022], white blood cell count [OR 0.802; 95 % CI 0.670-0.960; p = 0.016], and pneumomediastinum [OR 16.514; 95 % CI 1.330-205.027; p = 0. 029] were independently associated with hospital mortality. Conclusions: Mortality rate for non-HIV PJP patients requiring ICU admission was still high. Poor prognostic factors included age, white blood cell count and pneumomediastinum.
第一作者单位：[1]Medical ICU, Peking Union Medical College Hospital, Peking Union MedicalCollege and Chinese Academy of Medical Sciences, 1 Shuaifuyuan,Dongcheng district, Beijing 100730, China
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推荐引用方式(GB/T 7714)：
Li Weng,Xu Huang,Lie Chen,et al.Prognostic factors for severe Pneumocystis jiroveci pneumonia of non-HIV patients in intensive care unit: a bicentric retrospective study[J].BMC INFECTIOUS DISEASES.2016,16:doi:10.1186/s12879-016-1855-x.
APA：
Li Weng,Xu Huang,Lie Chen,Li-Qin Feng,Wei Jiang...&Bin Du.(2016).Prognostic factors for severe Pneumocystis jiroveci pneumonia of non-HIV patients in intensive care unit: a bicentric retrospective study.BMC INFECTIOUS DISEASES,16,
MLA：
Li Weng,et al."Prognostic factors for severe Pneumocystis jiroveci pneumonia of non-HIV patients in intensive care unit: a bicentric retrospective study".BMC INFECTIOUS DISEASES 16.(2016)
