单位：[1]Department of Ultrasound, Peking UnionMedical College Hospital, Peking Union MedicalCollege, Chinese Academy of Medical Sciences,Beijing, People’s Republic of China[2]Department of Ultrasound, China-JapanFriendship Hospital, Beijing, People’s Republicof China[3]Department of General Surgery,Peking Union Medical College Hospital, PekingUnion Medical College, Chinese Academy ofMedical Sciences, Beijing, People’s Republic ofChina[4]Department of Pathology, Peking UnionMedical College Hospital, Peking Union MedicalCollege, Chinese Academy of Medical Sciences,Beijing, People’s Republic of China[5]Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences ChineseAcademy of Medical Sciences, School of BasicMedicine Peking Union Medical College, Beijing,People’s Republic of China[6]Department ofMedical Oncology, Peking Union MedicalCollege Hospital, Peking Union MedicalCollege, Chinese Academy of Medical Sciences,Beijing, People’s Republic of China[7]KeyLaboratory of Endocrinology of NationalHealth Commission, Department ofEndocrinology, Peking Union Medical CollegeHospital, Chinese Academy of Medical Scienceand Peking Union Medical College, Beijing,People’s Republic of China
Objective: Investigate the CEUS enhancement patterns of PDAC and analyse correlations between the CEUS enhancement pattern and both the degree of tumour tissue differentiation and overall survival (OS). Methods: The study included 56 patients with locally advanced PDAC, performed conventional ultrasound and CEUS, and analysed characteristics of the CEUS enhancement patterns. In addition, clinical data, such as serum level of CA19-9, TNM stage were collected, and patients' survival times were followed up. TICs of dynamic CEUS images were acquired using image processing software to obtain the peak, TP, sharpness, and AUC. Correlations of the CEUS enhancement patterns of PDAC with the degree of differentiation of tumour tissue and OS were quantitatively analysed, as were the correlations of the TIC parameters and CEUS enhancement patterns with OS. Results: Enhancement in the arterial phase included iso-enhancement (30.3%) and hypo enhancement (69.6%), and was not significantly correlated with sex, age at disease onset, or lesion size. Also was not significantly correlated with tumour tissue differentiation. Clear survival times were obtained for 50 patients during follow-up, and the median survival time was significantly longer for the patients with iso-enhancement than hypo-enhancement. Among the TIC parameters, peaktumour, sharpnesstumour, AEsharpness, and REsharpness differed significantly between the group with iso-enhancement and hypo-enhancement (p < 0.05). Conclusion: The CEUS enhancement patterns of PDAC in the arterial phase include isoenhancement and hypo-enhancement. Enhancement pattern was not significantly correlated with the degree of differentiation of tumour tissue, but patient survival time differed significantly between the two enhancement patterns, with longer survival for patients with iso-enhancement.
基金：
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-I2M-3-005, 2020-I2M-CT-B-039]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873902]
第一作者单位：[1]Department of Ultrasound, Peking UnionMedical College Hospital, Peking Union MedicalCollege, Chinese Academy of Medical Sciences,Beijing, People’s Republic of China[2]Department of Ultrasound, China-JapanFriendship Hospital, Beijing, People’s Republicof China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ultrasound, Peking UnionMedical College Hospital, Peking Union MedicalCollege, Chinese Academy of Medical Sciences,Beijing, People’s Republic of China[*1]Department of Ultrasound, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhou Tongtong,Tan Li,Gui Yang,et al.Correlation Between Enhancement Patterns on Transabdominal Ultrasound and Survival for Pancreatic Ductal Adenocarcinoma[J].CANCER MANAGEMENT and RESEARCH.2021,13:6823-6832.doi:10.2147/CMAR.S307079.
APA：
Zhou, Tongtong,Tan, Li,Gui, Yang,Zhang, Jing,Chen, Xueqi...&Jiang, Yuxin.(2021).Correlation Between Enhancement Patterns on Transabdominal Ultrasound and Survival for Pancreatic Ductal Adenocarcinoma.CANCER MANAGEMENT and RESEARCH,13,
MLA：
Zhou, Tongtong,et al."Correlation Between Enhancement Patterns on Transabdominal Ultrasound and Survival for Pancreatic Ductal Adenocarcinoma".CANCER MANAGEMENT and RESEARCH 13.(2021):6823-6832
