单位：[1]Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China[2]Evidence-Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China[3]WHOCollaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou, China[4]Chinese GRADE Centre, Lanzhou University, Lanzhou, China[5]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China广东省中医院[6]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[7]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China广东省中医院[8]First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China[9]Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China[10]Evidence-Based Medicine Center, School of BasicMedical Sciences, Lanzhou University, Lanzhou, China[11]Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China[12]Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China[13]Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China[14]Beijing Ditan Hospital Capital Medical University, Beijing, China[15]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China[16]Beijing Youan Hospital, Capital Medical University, Beijing, China[17]Wuhan Hospital of Traditional Chinese Medicine,Wuhan, China[18]First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China[19]The First Hospital of Lanzhou University, Lanzhou, China[20]Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing, China[21]Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China[22]Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China[23]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China[24]Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China[25]Department of RespiratoryMedicine, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, China[26]Guangzhou Eighth People′s Hospital, Guangzhou, China[27]China Academy of Chinese Medical Sciences, Beijing, China[28]Hubei Provincial Hospital of Integrated Traditional Chinese andWesternMedicine, Wuhan, China[29]China-Japan Friendship Hospital, Beijing, China[30]Evidence-Based Medicine Center of Tianjin University of Traditional Chinese Medicine, Tianjin, China[31]Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China
Background The coronavirus disease 2019 (COVID-19) has turned into a pandemic and resulted in huge death tolls and burdens. Integrating Chinese and western medicine has played an important role in the fight against the COVID-19 pandemic. Purpose We aimed to develop a living evidence-based guideline of integrating Chinese and western medicine for COVID-19. Study design Living evidence-based guideline. Methods This living guideline was developed using internationally recognized and accepted guideline standards, dynamically monitoring the release of new clinical evidence, and quickly updating the linked living systematic review, evidence summary tables, and recommendations. Modified Delphi method was used to reach consensus for all recommendations. The certainty of the evidence, resources, and other factors were fully considered, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to rate the certainty of evidence and the strength of recommendations. Results The first version of this living guidance focuses on patients who are mild or moderate COVID-19. A multidisciplinary guideline development panel was established. Ten clinical questions were identified based on the status of evidence and a face-to-face experts' consensus. Finally, nine recommendations were reached consensus, and were formulated from systematic reviews of the benefits and harms, certainty of evidence, public accessibility, policy supports, feedback on proposed recommendations from multidisciplinary experts, and consensus meetings. Conclusion This guideline panel made nine recommendations, which covered five traditional Chinese medicine (TCM) prescription granules/decoction (MXXFJD, QFPD, XFBD, TJQW, and JWDY), three Chinese patent medicines (LHQW granules/capsule, JHQG granules, and LHQK granules), and one Chinese herbal injection (XBJ injection). Of them, two were strongly recommended (LHQW granules/capsule and QFPD decoction), and five were weakly recommended (MXXFJD decoction, XFBD decoction, JHQG granules, TJQW granules, and JWDY decoction) for the treatment of mild and moderate COVID-19; two were weakly recommended against (XBJ injection and LHQK granules) the treatment of mild and moderate COVID-19. The users of this living guideline are most likely to be clinicians, patients, governments, ministries, and health administrators.
基金：
China National Centre for Biotechnology Development [2019YFC1709805, 2019YFC1709802]; State Key Laboratory of Dampness Syndrome of Chinese Medicine [ZH2019ZZ04, SZ2020ZZ09]
第一作者单位：[1]Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China[2]Evidence-Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China[3]WHOCollaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou, China[4]Chinese GRADE Centre, Lanzhou University, Lanzhou, China
共同第一作者：
通讯作者：
通讯机构：[5]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China[6]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[7]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China[*1]Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120, China.[*2]The StateKey Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital ofGuangzhou University of Chinese Medicine,Guangzhou 510120, China.
推荐引用方式(GB/T 7714)：
Long Ge,Hongfei Zhu,Qi Wang,et al.Integrating Chinese and western medicine for COVID-19: A living evidence-based guideline (version 1)[J].JOURNAL of EVIDENCE BASED MEDICINE.2021,14(4):313-332.doi:10.1111/jebm.12444.
APA：
Long Ge,Hongfei Zhu,Qi Wang,Mengting Li,Jianxiong Cai...&Darong Wu.(2021).Integrating Chinese and western medicine for COVID-19: A living evidence-based guideline (version 1).JOURNAL of EVIDENCE BASED MEDICINE,14,(4)
MLA：
Long Ge,et al."Integrating Chinese and western medicine for COVID-19: A living evidence-based guideline (version 1)".JOURNAL of EVIDENCE BASED MEDICINE 14..4(2021):313-332
