高级检索
当前位置: 首页 > 详情页

Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

单位: [1]Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China, [2]Department of Reproductive Medicine, Dalian Maternal and Children’s Centre, Dalian, China, [3]Graduate School of Heilongjiang University of Chinese Medicine, Harbin, China, [4]Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing, China, [5]Department of Reproductive Medicine, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, China
出处:
ISSN:

关键词: ovarian cancer metabolite Graph convolutional network support vector machine prediction

摘要:
Ovarian cancer is one of the three most malignant tumors of the female reproductive system. At present, researchers do not know its pathogenesis, which makes the treatment effect unsatisfactory. Metabolomics is closely related to drug efficacy, safety evaluation, mechanism of action, and rational drug use. Therefore, identifying ovarian cancer-related metabolites could greatly help researchers understand the pathogenesis and develop treatment plans. However, the measurement of metabolites is inaccurate and greatly affects the environment, and biological experiment is time-consuming and costly. Therefore, researchers tend to use computational methods to identify disease-related metabolites in large scale. Since the hypothesis that similar diseases are related to similar metabolites is widely accepted, in this paper, we built both disease similarity network and metabolite similarity network and used graph convolutional network (GCN) to encode these networks. Then, support vector machine (SVM) was used to identify whether a metabolite is related to ovarian cancer. The experiment results show that the AUC and AUPR of our method are 0.92 and 0.81, respectively. Finally, we proposed an effective method to prioritize ovarian cancer-related metabolites in large scale.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版
大类 | 2 区 生物
小类 | 2 区 发育生物学 3 区 细胞生物学
最新[2025]版:
大类 | 2 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
JCR分区:
出版当年[2019]版:
Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY
最新[2023]版:
Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2019版] 出版当年五年平均[2015-2019] 出版前一年[2018版] 出版后一年[2020版]

第一作者:
第一作者单位: [1]Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China,
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:1320 今日访问量:0 总访问量:816 更新日期:2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有:重庆聚合科技有限公司 渝ICP备12007440号-3 地址:重庆市两江新区泰山大道西段8号坤恩国际商务中心16层(401121)