单位:[1]Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China,[2]Department of Reproductive Medicine, Dalian Maternal and Children’s Centre, Dalian, China,[3]Graduate School of Heilongjiang University of Chinese Medicine, Harbin, China,[4]Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室全科医学科全科医学科首都医科大学附属北京友谊医院[5]Department of Reproductive Medicine, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, China
Ovarian cancer is one of the three most malignant tumors of the female reproductive system. At present, researchers do not know its pathogenesis, which makes the treatment effect unsatisfactory. Metabolomics is closely related to drug efficacy, safety evaluation, mechanism of action, and rational drug use. Therefore, identifying ovarian cancer-related metabolites could greatly help researchers understand the pathogenesis and develop treatment plans. However, the measurement of metabolites is inaccurate and greatly affects the environment, and biological experiment is time-consuming and costly. Therefore, researchers tend to use computational methods to identify disease-related metabolites in large scale. Since the hypothesis that similar diseases are related to similar metabolites is widely accepted, in this paper, we built both disease similarity network and metabolite similarity network and used graph convolutional network (GCN) to encode these networks. Then, support vector machine (SVM) was used to identify whether a metabolite is related to ovarian cancer. The experiment results show that the AUC and AUPR of our method are 0.92 and 0.81, respectively. Finally, we proposed an effective method to prioritize ovarian cancer-related metabolites in large scale.
基金:
Scientific Research Projects of National Clinical Research Base of Chinese Medicine of Health Commission of Henan Province [2021JDZY101]; Doctoral research fund of the First Affiliated Hospital of Henan University of Chinese Medicine [2021BSJJ003]
第一作者单位:[1]Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China,
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Chen Jingjing,Chen Yingying,Sun Kefeng,et al.Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network[J].FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY.2021,9:doi:10.3389/fcell.2021.753221.
APA:
Chen, Jingjing,Chen, Yingying,Sun, Kefeng,Wang, Yu,He, Hui...&Bi, Yanli.(2021).Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network.FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY,9,
MLA:
Chen, Jingjing,et al."Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network".FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY 9.(2021)