Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice
单位：[1]Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China[2]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
Renal fibrosis is a critical pathological process lead to a progressive loss of renal function. Jolkinolide B (JB) is a natural compound with anti-inflammatory activity from Euphorbia fischeriana Steud. The study evaluated the effect of JB on renal fibrosis in mice with unilateral ureteral obstruction (UUO). The results showed that JB could decrease renal fibrotic area, reduce phosphorylation of NF-kappa B p65 and the release of TNF-alpha, IL-6 and IL-1 beta, restore the expression of vementin, alpha-SMA and E-cadherin, as well as TGF-beta 1 and p-smad2/3. In conclusion, JB might reduce renal fibrosis by inhibiting inflammation induced by NF-kappa B pathway and EMT mediated by TGF-beta 1/Smad pathway. [GRAPHICS] .
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82104483, 81872761, 81960633, 81773958]; Open project of the State Key Laboratory of Natural Medicine Active Substances and Functions [GTZK202001]; G20 Engineering Innovation Research Project of Beijing Municipal Science & Technology Commission [Z181100002218029]; Elite Medical Professionals Open Project of China-Japan Friendship Hospital [ZRJY2021-BJ06, ZRJY2021-TD06]
第一作者单位：[1]Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China[2]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[2]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Li Mei,Yan Yu,He Jun,et al.Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice[J].JOURNAL of ASIAN NATURAL PRODUCTS RESEARCH.2022,24(1):76-87.doi:10.1080/10286020.2021.2016715.
APA：
Li, Mei,Yan, Yu,He, Jun,Wang, Yu-Ming,Guo, Yu-Xuan...&Xu, Jie-Kun.(2022).Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice.JOURNAL of ASIAN NATURAL PRODUCTS RESEARCH,24,(1)
MLA：
Li, Mei,et al."Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice".JOURNAL of ASIAN NATURAL PRODUCTS RESEARCH 24..1(2022):76-87
