单位：[1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China[2]Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China[3]Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[4]Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, China[5]Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, Shanghai, China
This study aimed to develop a more effective screening model for moderate-to-severe obstructive sleep apnea (OSA) based on the best tool among Epworth Sleepiness Scale (ESS), NoSAS score and STOP-BANG questionnaire (SBQ).This study screened 2,031 consecutive subjects referred with suspected OSA from 2012 to 2016, including the test cohort from 2012 to 2014 and the validation cohort from 2014 to 2016. Anthropometric measurements, polysomnographic data, ESS, NoSAS scores and SBQ scores were recorded. Receiver operating characteristic curve analyses were performed and the final predictive models were verified in a validation cohort.A total of 1,840 adults were finally included. The performance of ESS, NoSAS score and SBQ in screening OSA was compared. The diagnostic accuracy of SBQ was superior to ESS and NoSAS. A predictive model based on SBQ yielded an area under the curve (AUC) of 0.931 (95% CI: 0.915-0.946), and the sensitivity and specificity were 84.47 (95% CI: 81.4-87.2) and 87.36 (95% CI: 83.9-90.3) respectively. In the validation cohort, the AUC was 0.955 (95% CI: 0.938-0.969), with a sensitivity and specificity of 86.79 (95% CI: 83.2-89.9) and 90.88 (95% CI: 87.2-93.8) respectively. In addition, the model performed moderately in screening mild OSA with the AUC being 0.771 (95% CI: 0.721-0.815).The SBQ was effective in screening moderate-to-severe OSA. And a SBQ -based predictive model afforded excellent diagnostic efficacy, which could be applied in clinical practice.2022 Journal of Thoracic Disease. All rights reserved.
基金：
National Key R&D Program of China (No. 2017YFC0112500), National Natural Science Foundation of China (Nos. 81770987, 81700896, 81701306, and 81770988), Shanghai Municipal Commission of Science and Technology (No. 18DZ2260200), Shanghai Shenkang Hospital Development Center (No. 16CR3103B), Innovation Program of Shanghai Municipal Education Commission (No. 2017-01-07-00-02-E00047), multi-center clinical research project from school of medicine, Shanghai Jiao Tong University (No. DLY201502) and Shanghai Shen-Kang Hospital Management Center Project (No. SHDC12015101).
第一作者单位：[1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China[2]Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China[3]Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China[2]Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China[5]Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, Shanghai, China[*1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.[*2]Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
推荐引用方式(GB/T 7714)：
Wang Yuyu,Zou Juanjuan,Xu Huajun,et al.An effective model for screening moderate-to-severe obstructive sleep apnea based on the STOP-BANG questionnaire[J].Journal Of Thoracic Disease.2022,14(8):3066-3074.doi:10.21037/jtd-20-2027.
APA：
Wang Yuyu,Zou Juanjuan,Xu Huajun,Jiang Cuiping,Yi Hongliang...&Yin Shankai.(2022).An effective model for screening moderate-to-severe obstructive sleep apnea based on the STOP-BANG questionnaire.Journal Of Thoracic Disease,14,(8)
MLA：
Wang Yuyu,et al."An effective model for screening moderate-to-severe obstructive sleep apnea based on the STOP-BANG questionnaire".Journal Of Thoracic Disease 14..8(2022):3066-3074
