Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population
单位：[1]Department of Geriatrics, The First Affiliated Hospital of Chongqing MedicalUniversity, Chongqing, China[2]Department of Cardiology, General Hospital ofChinese People’s Liberation Army, No.28 Fu Xing Road, Beijing 100853,China[3]Department of Ophthalmology, 958 Hospital of PLA ARMY,Chongqing, China[4]Department of Cardiology, Beijing Friendship Hospital,Capital Medical University, Beijing, China临床科室心血管中心心内科首都医科大学附属北京友谊医院
BackgroundThe mitochondrial genotype 5178 cytosine/adenine (5178 C>A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C>A and clinical risk factors on the susceptibility of essential hypertension in Chinese general population.Materials and MethodsThe relationship between the ND2 5178 C>A variation and the risk of hypertension was investigated in 817 hypertensives and 821 matched normotensives. The interactive effects between ND2 5178 C>A and clinical risk factors were evaluated.ResultsThe ND2 5178 A allele was more frequent in normotensives than in hypertensives (32.64% vs. 24.24%; adjusted OR: 0.62, 95% CI: 0.49-0.79, P=1.3x10(-4)). After stratification, the significant association between ND2 5178 C>A and hypertension was found only in current smokers (OR: 0.44, 95% CI: 0.31-0.62), but not in non-current smokers (p<0.01 for interaction). Smoking status (OR: 1.51, 95% CI: 1.11-2.06) and high triglycerides (OR: 1.57, 95% CI: 1.10-2.24) were found independently associated with hypertension only in carriers of 5178 C allele but not in carriers of 5178 A allele.ConclusionsIn conclusion, ND2 5178 A allele could confer a lower risk for essential hypertension in Chinese by the interaction with smoking status. The higher risk of hypertension imposed by smoking and high TG may be altered by ND2 5178 A allele.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870249]; National Key RD Program of China [2017YFC0908700, 2017YFC0908703]
第一作者单位：[1]Department of Geriatrics, The First Affiliated Hospital of Chongqing MedicalUniversity, Chongqing, China[2]Department of Cardiology, General Hospital ofChinese People’s Liberation Army, No.28 Fu Xing Road, Beijing 100853,China
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推荐引用方式(GB/T 7714)：
Chen Xi,He Xiang-Yu,Zhu Chao,et al.Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population[J].BMC MEDICAL GENETICS.2019,20:doi:10.1186/s12881-019-0838-3.
APA：
Chen, Xi,He, Xiang-Yu,Zhu, Chao,Zhang, Yusong,Li, Zongbin...&Li, Yang.(2019).Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population.BMC MEDICAL GENETICS,20,
MLA：
Chen, Xi,et al."Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population".BMC MEDICAL GENETICS 20.(2019)
