Target genes involved in corticosterone-induced PC12 cell viability and neurite disorders: A potential molecular mechanism of major depressive disorder
单位：[1]Beijing Center for Physical and Chemical Analysis, Bejing 100089, China[2]Beijing Biodonor Biotech Ltd., Beijing 101111, China .[3]Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院[4]Department of Biological Sciences, Southeastern Oklahoma State University, Durant, OK 74701, USA
Past studies confirmed that hypothalamic-pituitary-adrenal (HPA)-axis hormones involved in major depressive disorder (MDD) development. This study used corticosterone treated PC12 cells to explore the potential role of MAPK signal transduction pathway in response to corticosterone stimulation. The results showed that both live cell numbers and cellular neurite outgrowth were remarkably reduced in response to corticosterone treatments. qPCR results demonstrated that the expression levels of four MAPK pathway genes were significantly increased after corticosterone stimulation. In conclusion, glucocorticolds stimulation can affect neuronal cell viability and neurite outgrowth due to the over expression of a group of MAPK pathway genes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
基金：
Beijing Academy of Science and Technology Overseas Talent Special Funding Project [OTP-2013-002]; Beijing Academy of Science and Technology Key Projects Funding [20130-12]; Southeastern Faculty Research Grant [A-6-0502-1512-005]
第一作者单位：[1]Beijing Center for Physical and Chemical Analysis, Bejing 100089, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Mingzhen,Zhou Jianjun,Qian Jialin,et al.Target genes involved in corticosterone-induced PC12 cell viability and neurite disorders: A potential molecular mechanism of major depressive disorder[J].PSYCHIATRY RESEARCH.2016,235:206-208.doi:10.1016/j.psychres.2015.11.044.
APA：
Li, Mingzhen,Zhou, Jianjun,Qian, Jialin,Cheng, Xiaoyan,Wu, Huijuan...&Wu, Ning.(2016).Target genes involved in corticosterone-induced PC12 cell viability and neurite disorders: A potential molecular mechanism of major depressive disorder.PSYCHIATRY RESEARCH,235,
MLA：
Li, Mingzhen,et al."Target genes involved in corticosterone-induced PC12 cell viability and neurite disorders: A potential molecular mechanism of major depressive disorder".PSYCHIATRY RESEARCH 235.(2016):206-208
