单位：[1]Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Beijing, China北京朝阳医院[2]Department of Surgery Intensive Care Unit, State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[3]Department of Surgery Intensive Care Unit, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China首都医科大学附属安贞医院[4]Department of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, National Clinical Research Center for Respiratory Medicine, Beijing, China
Background and AimsDynamic hyperinflation (DH) is an important pathophysiological characteristic of chronic obstructive pulmonary disease (COPD). There is increasing evidence that DH has negative effects on exercise performance and quality of life. The objective of this study was to explore effects of DH on exercise capacity and quality of life in stable COPD patients. MethodsFifty-eight COPD patients and 20 matched healthy individuals underwent pulmonary function test, 6-min walk test and symptom-limited cardiopulmonary exercise test (CPET). End-expiratory lung volume/total lung capacity ratio (EELVmax/TLC) at peak exercise of CPET was evaluated, and EELVmax/TLC75% was defined as severe dynamic hyperinflation (SDH)'. ResultsOf the 58 patients studied, 29 (50.0%) presented with SDH (SDH+ group, EELVmax/TLC 79.603.60%), having worse maximal exercise capacity reflected by lower peakload, maximal oxygen uptake (VO(2)max), maximal carbon dioxide output (VCO(2)max) and maximal minute ventilation (VEmax) than did those without SDH (SDH- group, EELVmax/TLC 67.44 +/- 6.53%). The EELVmax/TLC ratio at peak exercise had no association with variables of pulmonary function and 6-min walk distance (6MWD), but correlated inversely with peakload, VO(2)max, VCO(2)max and VEmax (r=-0.300 similar to-0.351, P<0.05). Although no significant differences were observed, patients with EELVmax/TLC75% tended to have higher COPD assessment test score (15.07 +/- 6.55 vs 13.28 +/- 6.59, P=0.303). ConclusionsDH develops variably during exercise and has a greater impact on maximal exercise capacity than 6MWD, even in those with the same extent of pulmonary function impairment at rest.
第一作者单位：[1]Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Beijing, China[2]Department of Surgery Intensive Care Unit, State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
通讯作者：
通讯机构：[1]Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Beijing, China[4]Department of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, National Clinical Research Center for Respiratory Medicine, Beijing, China[*1]Department of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, National Clinical Research Center for Respiratory Medicine, 2 Yinghua Dongjie, Chaoyang District, 100029, Beijing, China.[*2]Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, 100020, Beijing, China.
推荐引用方式(GB/T 7714)：
Zhao Li,Peng Liyue,Wu Baomei,et al.Effects of dynamic hyperinflation on exercise capacity and quality of life in stable COPD patients[J].CLINICAL RESPIRATORY JOURNAL.2016,10(5):579-588.doi:10.1111/crj.12260.
APA：
Zhao, Li,Peng, Liyue,Wu, Baomei,Bu, Xiaoning&Wang, Chen.(2016).Effects of dynamic hyperinflation on exercise capacity and quality of life in stable COPD patients.CLINICAL RESPIRATORY JOURNAL,10,(5)
MLA：
Zhao, Li,et al."Effects of dynamic hyperinflation on exercise capacity and quality of life in stable COPD patients".CLINICAL RESPIRATORY JOURNAL 10..5(2016):579-588
