Although the ability of endogenous CD4(-)CD8(-) double negative (DN) T cells to suppress B cells has been documented, the extent to which ex vivo converted DN T cells suppress B cells activity is still being explored. The aim of this study was to determine whether and what extent ex vivo converted CD4(-)CD8(-) DN T cells suppress B cell activation and antibody production. We found that ex vivo converted ON T cells suppressed proliferation of activated B cells in a perforin and cell-cell contact dependent manner. In addition, ex vivo converted DN T cells significantly inhibited the production of IgG by stimulated B cells. This study provides evidence that ex vivo converted CD4(-)CD8(-) double negative T cells can down-regulate immune responses by suppressing B cell proliferation and IgG production, and supports efforts to develop ex vivo DNT cell therapies. (C) 2014 Elsevier B.V. All rights reserved.
第一作者单位：[1]Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, Beijing 100044, Peoples R China
通讯作者：
通讯机构：[1]Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, Beijing 100044, Peoples R China[*1]Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China
推荐引用方式(GB/T 7714)：
Li WenXia,Tian Yue,Li Zhao,et al.Ex vivo converted double negative T cells suppress activated B cells[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2014,20(1):164-169.doi:10.1016/j.intimp.2014.02.034.
APA：
Li WenXia,Tian Yue,Li Zhao,Gao Jie,Shi Wen...&Zhang Dong.(2014).Ex vivo converted double negative T cells suppress activated B cells.INTERNATIONAL IMMUNOPHARMACOLOGY,20,(1)
MLA：
Li WenXia,et al."Ex vivo converted double negative T cells suppress activated B cells".INTERNATIONAL IMMUNOPHARMACOLOGY 20..1(2014):164-169
