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Promoter of TFPI-2 is Hypermethylated in Chinese Pediatric Acute Myeloid Leukemia

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收录情况： ◇ SCIE

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单位： [1]Soochow Univ, Childrens Hosp, Dept Hematol & Oncol, Suzhou, Peoples R China [2]Chinese Acad Sci, Dept Cell & Mol Biol, Canc Inst Hosp, Peking Union Med Coll, Beijing 100864, Peoples R China [3]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China [4]Nanjing Med Univ, Clin Sch 2, Translat Res Ctr, Hosp 2, Nanjing, Peoples R China

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关键词： acute myeloid leukemia tissue factor pathway inhibitor-2 hypermethylation

摘要：

Human tissue factor pathway inhibitor-2 (TFPI-2) has been implicated as a metastasis-associated gene in many types of tumors. In this study, we investigated whether TFPI-2 was inactivated epigenetically in pediatric acute myeloid leukemia (AML). Methylation status was investigated by methylation-specific polymerase chain reaction and bisulfate genomic sequencing. TFPI-2 was aberrantly methylated in 50% (3/6) of AML cell lines. Aberrant methylation of TFPI-2 promoter was detected in 71.6% (48/67) of the Chinese pediatric AML patients. TFPI-2 transcript was significantly lower in AML group compared with controls (3.44 vs. 32.8, P<0.001). Patients with methylated TFPI-2 gene had significantly lower TFPI-2 transcript than those patients without methylated TFPI-2 (P=0.04). Promoter hypermethylation of TFPI-2 is frequent and specific event in pediatric AML.

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出版当年[2011]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区肿瘤学 4 区儿科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区肿瘤学 4 区儿科

JCR分区：

出版当年[2010]版：

Q3 PEDIATRICS Q4 ONCOLOGY Q4 HEMATOLOGY

最新[2023]版：

Q3 PEDIATRICS Q4 HEMATOLOGY Q4 ONCOLOGY

影响因子： 最新[2023版] 0.9 最新五年平均[2021-2025] 1 出版当年[2010版] 0.998 出版当年五年平均[2006-2010] 1.28 出版前一年[2009版] 1.022 出版后一年[2011版] 1.159

第一作者：

第一作者单位： [1]Soochow Univ, Childrens Hosp, Dept Hematol & Oncol, Suzhou, Peoples R China [2]Chinese Acad Sci, Dept Cell & Mol Biol, Canc Inst Hosp, Peking Union Med Coll, Beijing 100864, Peoples R China

通讯作者：

通讯机构： [1]Soochow Univ, Childrens Hosp, Dept Hematol & Oncol, Suzhou, Peoples R China [4]Nanjing Med Univ, Clin Sch 2, Translat Res Ctr, Hosp 2, Nanjing, Peoples R China

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