单位：[1]Capital Med Univ, Dept Urol, Beijing Friendship Hosp, Beijing 100050, Peoples R China首都医科大学附属北京友谊医院[2]Capital Med Univ, Dept Pathol, Beijing 100069, Peoples R China
To determine the synergy of 5-aza-2'-deoxycytidine (DAC) and paclitaxel (M) against prostate carcinoma (PC) cells by isobolographic analysis. We demonstrated that DAC could significantly increase the susceptibility of PC cells to M, and confirmed the synergy of DAC and PTX DAC enhanced the PTX induced up-regulation of caspase activity and anti-proliferative effect, resulting in an increase of cells in subG1 and G2/M phases. In addition, the synergy was observed in both androgen-dependent and -independent PC cell lines. It suggested that combination chemotherapy with DAC and PTX might be a new strategy to improve the clinical response rate of PC. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved.
基金：
Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars
第一作者单位：[1]Capital Med Univ, Dept Urol, Beijing Friendship Hosp, Beijing 100050, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Shang Donghao,Liu Yuting,Liu Qingjun,et al.Synergy of 5-aza-2 '-deoxycytidine (DAC) and paclitaxel in both androgen-dependent and -independent prostate cancer cell lines[J].CANCER LETTERS.2009,278(1):82-87.doi:10.1016/j.canlet.2008.12.034.
APA：
Shang, Donghao,Liu, Yuting,Liu, Qingjun,Zhang, Fengbo,Feng, Lang...&Tian, Ye.(2009).Synergy of 5-aza-2 '-deoxycytidine (DAC) and paclitaxel in both androgen-dependent and -independent prostate cancer cell lines.CANCER LETTERS,278,(1)
MLA：
Shang, Donghao,et al."Synergy of 5-aza-2 '-deoxycytidine (DAC) and paclitaxel in both androgen-dependent and -independent prostate cancer cell lines".CANCER LETTERS 278..1(2009):82-87
医学