单位：[a]Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China首都医科大学附属天坛医院[b]Department of Gastroenterology, Jincheng People's Hospital, Jincheng 048000, China[c]Department of Intervention Therapy, Zezhou People's Hospital, Jincheng 048026, China[d]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院
Immune surveillance cells in the tumor microenvironment play an important role in inhibiting tumorigenesis and metastasis, but their anti-tumoral effects are impaired. The anti-tumoral effects of innate immune cells and adaptive immune cells in the immune microenvironment of gastric cancer are also impaired. Their degree of functional impairment is closely related to the prognosis of gastric cancer. Multiple factors inhibit the antitumoral effects of immune surveillance cells, such as decreased numbers of immune surveillance cells, reduced activating receptors, decreased secretion of pro-inflammatory cytokines, increased apoptosis, elevated expression of coinhibitory molecules on cancer cells or immunosuppressive cells, increased secretion of inhibitory cytokines, impaired antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by antigen-presenting cells (APCs) and pro-tumoral polarization of cells with functional plasticity. These factors can potentially combine to suppress the immune surveillance cells' functions. However, there are conflicting conclusions on the effects of immune surveillance cells on gastric cancer cells. These contradictions are partly due to the heterogeneity of the tumor microenvironment.
第一作者单位：[a]Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[b]Department of Gastroenterology, Jincheng People's Hospital, Jincheng 048000, China
通讯作者：
通讯机构：[a]Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[d]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China[*1]Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing 100070, China[*2]Beijing Friendship Hospital, Capital Medical University, No.95 Yongan Road, Xicheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Xueke Fan,Jiangtao Jin,Lichen Yan,et al.The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer[J].CLINICAL IMMUNOLOGY.2020,219:doi:10.1016/j.clim.2020.108551.
APA：
Xueke Fan,Jiangtao Jin,Lichen Yan,Lei Liu,Qin Li&Youqing Xu.(2020).The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer.CLINICAL IMMUNOLOGY,219,
MLA：
Xueke Fan,et al."The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer".CLINICAL IMMUNOLOGY 219.(2020)
