单位：[1]Department of Orthopedic, Surgery Graduate School of Peking Union Medical College, China-Japan Friendship institute of Clinical Medicine, 2 Yinghuadong Road, Chaoyang District, 100029 Beijing, China.[2]Department of Intensive Care Unit, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, 354 North Road, Hongqiao District, Tianjin 300120, China. [3]Department of Orthopaedic Surgery, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China. [4]Department of Gastroenterology, Henan Provincial People’s Hospital, Weiwu road No 7, Jinshui district, Zhengzhou City 450003, Henan province, China.
ObjectiveWe aimed to evaluate the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery.MethodsWe searched PubMed, Embase, Medline, Cochrane library, and Web of Science to identify randomized controlled trials that compared postoperative pain outcomes with or without IA Mg after knee arthroscopy. The primary outcomes were pain intensity at rest and with movement at different postoperative time points and cumulative opioid consumption within 24h after surgery. Secondary outcomes included the time to first analgesic request and side effects.ResultsIn total, 11 studies involving 677 participants met the eligibility criteria. Pain scores at rest and with movement 2, 4, 12, and 24h after surgery were significantly lower, doses of supplementary opioid consumption were smaller, and the time to first analgesic requirement was longer in the IA Mg group compared with the control group. No significant difference was detected regarding adverse reactions between the groups.ConclusionsIntra-articular magnesium is an effective and safe coadjuvant treatment for relieving postoperative pain intensity after arthroscopic knee surgery.Protocol registration at PROSPERO: CRD42020156403.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871830, 81672236, 82072524]; Biomedical Translational Engineering Research Center of BUCT-CJFH [RZ2020-02]; Graduate Innovation Foundation of Peking Union Medical College [2019-1002-91]
第一作者单位：[1]Department of Orthopedic, Surgery Graduate School of Peking Union Medical College, China-Japan Friendship institute of Clinical Medicine, 2 Yinghuadong Road, Chaoyang District, 100029 Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedic, Surgery Graduate School of Peking Union Medical College, China-Japan Friendship institute of Clinical Medicine, 2 Yinghuadong Road, Chaoyang District, 100029 Beijing, China.[3]Department of Orthopaedic Surgery, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Shi Lijun,Zhu Haiyun,Ma Jinhui,et al.Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials[J].JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH.2021,16(1):doi:10.1186/s13018-021-02264-1.
APA：
Shi, Lijun,Zhu, Haiyun,Ma, Jinhui,Shi, Li-Li,Gao, Fuqiang&Sun, Wei.(2021).Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials.JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH,16,(1)
MLA：
Shi, Lijun,et al."Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials".JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH 16..1(2021)
