单位：[1]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwai St, Beijing 100875, Peoples R China[2]China Acad Tradit Chinese Med, Inst Basic Res Clin Med, Beijing, Peoples R China[3]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China[4]Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China[5]Dongcheng Dist Community Hlth Serv Ctr, Beijing, Peoples R China[6]Shenzhen Univ, Sch Psychol & Soc, Shenzhen, Peoples R China[7]China North Ind Grp, Beijing Northern Hosp, Beijing, Peoples R China[8]Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Neurol, Beijing, Peoples R China[9]Capital Med Univ, Beijing Tiantan Hosp, Dept Nucl Med, Beijing, Peoples R China首都医科大学附属天坛医院[10]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China[11]China Japan Friendship Hosp, Dept Neurol, Beijing, Peoples R China[12]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China首都医科大学附属天坛医院[13]Banner Alzheimers Inst, Phoenix, AZ USA[14]Capital Med Univ, Sch Basic Med, Beijing, Peoples R China[15]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China首都医科大学附属天坛医院
Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.
基金：
National Key Research and Development Project of China [2018YFC1315200]; National Science Fund for DistinguishedYoung ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81625025]; Funds for International Cooperation and Exchange of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81820108034]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31971038]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z161100000216135]; Fundamental Research Funds for theCentral UniversitiesFundamental Research Funds for the Central Universities [2017XTCX04]
第一作者单位：[1]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwai St, Beijing 100875, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Caishui,Li Xin,Zhang Junying,et al.Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative[J].ALZHEIMERS & DEMENTIA.2021,17(10):1610-1618.doi:10.1002/alz.12326.
APA：
Yang, Caishui,Li, Xin,Zhang, Junying,Chen, Yaojing,Li, He...&Zhang, Zhanjun.(2021).Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.ALZHEIMERS & DEMENTIA,17,(10)
MLA：
Yang, Caishui,et al."Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative".ALZHEIMERS & DEMENTIA 17..10(2021):1610-1618
医学