单位：[1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China,[2]Department of Gynecologic Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China,河南省肿瘤医院[3]Departmentof Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China,河北医科大学第四医院[4]Department of Obstetrics and Gynecology,Xinqiao Hospital, Army Medical University, Chongqing, China,[5]Department of Obstetrics and Gynecology, Daping Hospital,Army Medical University, Chonqing, China,[6]Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital,Shenzhen, China,深圳市妇幼保健院深圳市康宁医院深圳医学信息中心[7]Department of Gynecology, Shenzhen Hospital of Southern Medical University, Shenzhen, China,南方医科大学深圳医院深圳市康宁医院深圳医学信息中心[8]Department of Gynecology, Shenzhen Sixth People’s Hospital, Shenzhen, China,深圳市康宁医院深圳医学信息中心[9]Department of Obstetrics andGynecology, China-Japan Friendship Hospital, Beijing, China,[10]Department of Epidemiology, College of Public Health,Guangzhou Medical University, Guangzhou, China,[11]Department of Obstetrics and Gynecology, Peking Union MedicalCollege Hospital, Peking Union Medical College, Beijing, China
Purpose: To examine the association between surgical volume and surgical and oncological outcomes of women with stage IB1 cervical cancer who underwent laparoscopic radical hysterectomy (LRH). Methods: We retrospectively analyzed the oncological outcomes of 1,137 patients with stage IB1 cervical cancer receiving LRH from 2004 to 2016. The surgical volume for each surgeon was defined as low [fewer than 50 surgeries, n = 392(34.5%)], mid [51-100 surgeries, n = 315(27.7%)], and high [100 surgeries or more, n = 430(37.8%)]. Surgical volume-specific survival was examined with Kaplan-Meier analysis, multivariable analysis, and propensity score matching. Results: The operative times of the high-volume group (227.35 +/- 7.796 min) were significantly shorter than that of the low- (272.77 +/- 4.887 min, p < 0.001) and mid-volume (255.86 +/- 4.981 min, p < 0.001) groups. Blood loss in the high-volume group (169.42 +/- 8.714 ml) was significantly less than that in the low-volume group (219.24 +/- 11.299 ml, p = 0.003). The 5-year disease-free survival (DFS) and overall survival (OS) in the low-volume, mid-volume, and high-volume groups were similar (DFS: 91.9, 86.7, and 89.2%, p = 0.102; OS: 96.4, 93.5, and 94.2%, p = 0.192). Multivariable analysis revealed surgical volume was not an independent risk factor for OS or DFS. The rate of intraoperative and postoperative complications was similar among the three groups (p = 0.210). Conclusions: Surgical volume of LRH may not be a prognostic factor for patients with stage IB1 cervical cancer. Surgery at high-volume surgeon is associated with decreased operative time and blood loss.
基金：
National Science and Technology Support Program of China [2014BAI05B03]; National Natural Science Fund of GuangdongNational Natural Science Foundation of Guangdong Province [2015A030311024]; Science and Technology Plan of Guangzhou [158100075]; Guangdong Medical Science and Technology Research Fund Project [A2020077]; Basic and Applied Basic Research Fund of Guangdong Province [2019A1515110337]; Chinese Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M660207, 2019C005]
第一作者单位：[1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Pengfei,Liu Jiaqi,Wang Li,et al.The Effect of Laparoscopic Radical Hysterectomy Surgical Volume on Oncology Outcomes in Early-Stage Cervical Cancer[J].FRONTIERS in SURGERY.2021,8:doi:10.3389/fsurg.2021.692163.
APA：
Li Pengfei,Liu Jiaqi,Wang Li,Kang Shang,Yang Ying...&Chen Chunlin.(2021).The Effect of Laparoscopic Radical Hysterectomy Surgical Volume on Oncology Outcomes in Early-Stage Cervical Cancer.FRONTIERS in SURGERY,8,
MLA：
Li Pengfei,et al."The Effect of Laparoscopic Radical Hysterectomy Surgical Volume on Oncology Outcomes in Early-Stage Cervical Cancer".FRONTIERS in SURGERY 8.(2021)
