单位：[1]Department of Dermatology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Cell lineage tracing and single-cell sequencing have been widely applied in development biology and oncology to reveal the molecular mechanisms in multiple basic biological processes and the differentiation of stem cells, as well as quantify the differences between single cells. They provide new methods for in-depth understanding of the origin of tumors, the heterogeneity of tumor cells, and the drug resistance mechanism of tumors, thus inspiring new strategies for tumor treatment. In this review, we summarized the progress of cell lineage tracing technology and single-cell sequencing technology in the research of malignant melanoma and cutaneous squamous cell carcinoma, attempting to spark new ideas for further research on skin tumors.
基金：
scientific and technological innovation leading talents of "Ten Thousand Talents Program" [2018-WRJH-1]; discipline construction project of Peking Union Medical College [xhxk201903]; China Postdoctoral Science Foundation [2021M703654]
第一作者单位：[1]Department of Dermatology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Ang,Liu Baoyi,Xu Jingkai,et al.Research Progress of Cell Lineage Tracing and Single-Cell Sequencing Technology in Malignant Skin Tumors[J].FRONTIERS IN SURGERY.2022,9:doi:10.3389/fsurg.2022.934828.
APA：
Li, Ang,Liu, Baoyi,Xu, Jingkai&Cui, Yong.(2022).Research Progress of Cell Lineage Tracing and Single-Cell Sequencing Technology in Malignant Skin Tumors.FRONTIERS IN SURGERY,9,
MLA：
Li, Ang,et al."Research Progress of Cell Lineage Tracing and Single-Cell Sequencing Technology in Malignant Skin Tumors".FRONTIERS IN SURGERY 9.(2022)
