单位：[1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China[2]Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China[3]School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China
Erythrosides A-G, seven undescribed oleanane-type triterpenoid saponins, were isolated from the seeds of Erythrophleum fordii. Their structures with absolute configurations were determined by extensive spectroscopic analysis including one-dimensional [1D] and two-dimensional [2D] nuclear magnetic resonance [NMR], high-resolution electrospray ionization mass spectroscopy [HR-ESI-MS] analysis, and chemical methods. Erythrosides A-G featured a diverse oligosaccharide chain containing 4-6 pentoses or hexoses at C-3 and a monoterpenic acid or a (E)-cinnamic acid unit at the C-21 position. Of particular interest, erythrosides A-C, E and F contained a rare alpha xylose in their sugar chains. The bioassay results indicated that erythrosides A-C showed moderate cytotoxic activities against human lung cancer cell line PC9 with IC50 values of 13.14, 16.67 and 17.59 mu M, respectively (the positive control, Taxol, IC50 = 0.60 nM).
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872761, 81960633]; National Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2019A1515011489]
第一作者单位：[1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China
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推荐引用方式(GB/T 7714)：
Chen Ze-Ping,Guo Lin-Bo,He Jun,et al.Triterpene saponins from the seeds of Erythrophleum fordii and their cytotoxic activities[J].PHYTOCHEMISTRY.2020,177:doi:10.1016/j.phytochem.2020.112428.
APA：
Chen, Ze-Ping,Guo, Lin-Bo,He, Jun,Xu, Jie-Kun,Li, Ya-Nan...&Tian, Hai-Yan.(2020).Triterpene saponins from the seeds of Erythrophleum fordii and their cytotoxic activities.PHYTOCHEMISTRY,177,
MLA：
Chen, Ze-Ping,et al."Triterpene saponins from the seeds of Erythrophleum fordii and their cytotoxic activities".PHYTOCHEMISTRY 177.(2020)
