A bacterial biofilm is one of the main reasons that many diseases are difficult to cure. Herein, a teicoplanin (TPN)-loaded self-adapting chitosan-based hydrogel (CPH) system, called TPN-CPH, was prepared by encapsulating antibacterial TPN into CPH. This TPN-CPH can effectively combat preformed biofilms in vitro of Staphylococcus aureus (S. aureus). It has a good therapeutic effect on full-thickness cutaneous wounds in vivo of mice infected with biofilms. In addition, TPN-CPH can accelerate wound healing by self-adapting the wound and providing a moist environment. The operation process of TPN-CPH is simple, and no external stimulation such as light and heat is needed in the treatment process, making it more convenient for clinical application. Furthermore, this is a challenge to use self-adapting hydrogels to adapt the micro-size channels of biofilms. TPN-CPH provides a chitosan-based self-adapting hydrogel system for loading drugs to kill bacteria in biofilms, and thus it is promising for infection control.
基金：
National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [21574008]; Key Program of Beijing Natural Science Foundation [Z200025]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [BHYC1705B]
第一作者单位：[1]Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Xia,Fu Ya-nan,Huang Lifei,et al.Combating Biofilms by a Self-Adapting Drug Loading Hydrogel[J].ACS APPLIED BIO MATERIALS.2021,4(8):6219-6226.doi:10.1021/acsabm.1c00540.
APA：
Li, Xia,Fu, Ya-nan,Huang, Lifei,Liu, Fang,Moriarty, Thomas Fintan...&Wang, Xing.(2021).Combating Biofilms by a Self-Adapting Drug Loading Hydrogel.ACS APPLIED BIO MATERIALS,4,(8)
MLA：
Li, Xia,et al."Combating Biofilms by a Self-Adapting Drug Loading Hydrogel".ACS APPLIED BIO MATERIALS 4..8(2021):6219-6226
