单位：[1]Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China[2]Department of Dermatology, Beijing Friendship Hospital, Beijing 100050, China临床科室皮肤性病科皮肤性病科首都医科大学附属北京友谊医院
alpha(s1)-Casein is a potential allergen to induce hypersensitivity in cow milk. We had identified alpha(s1)-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of alpha(s1)-casein in a BALB/c mouse model. The levels of specific IgE, mast cell proteinase, histamine and cytokines in sensitized mice were determined, and the clinical and pathological observation were evaluated. Results showed that the levels of specific IgE, mast cell proteinase, histamine, IL: 4. IL-5, IL-10 increased significantly with a dose-dependent trend. The local alveolar septum collapsed or thickened, and lymphatic foci were produced in the spleen and thymus, and the inflammatory cells infiltrated in small intestinal mucosa mesenchyme. In conclusion, the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 and some inflammatory factors could possibly serve as allergic biomarkers of alpha(s1)-casein, however, additional studies on signal transduction and gene expression are necessary in future. (C) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
基金：
This work was supported by National Science and Technology
Project in Rural Areas (China, 2018YFC1604205), and the National
Natural Science Foundation of China (Beijing, China; 31872886).
第一作者单位：[1]Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China
通讯作者：
通讯机构：[1]Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China[*1]College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
推荐引用方式(GB/T 7714)：
Guangyu Wang,Xiaofeng Yu,Yanjun Cong,et al.Cow milk alpha(s1)-casein induces allergic responses in a mouse model of atopy[J].Food Science and Human Wellness.2022,11(5):1282-1289.doi:10.1016/j.fshw.2022.04.006.
APA：
Guangyu Wang,Xiaofeng Yu,Yanjun Cong&Linfeng Li.(2022).Cow milk alpha(s1)-casein induces allergic responses in a mouse model of atopy.Food Science and Human Wellness,11,(5)
MLA：
Guangyu Wang,et al."Cow milk alpha(s1)-casein induces allergic responses in a mouse model of atopy".Food Science and Human Wellness 11..5(2022):1282-1289
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